MT1-MMP expression promotes tumor growth and angiogenesis through an up-regulation of vascular endothelial growth factor expression

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
N E SounniA Noël

Abstract

Membrane type 1 metalloprotease (MT1-MMP) is a transmembrane metalloprotease that plays a major role in the extracellular matrix remodeling, directly by degrading several of its components and indirectly by activating pro-MMP2. We investigated the effects of MT1-MMP overexpression on in vitro and in vivo properties of human breast adenocarcinoma MCF7 cells, which do not express MT1-MMP or MMP-2. MT1-MMP and MMP-2 cDNAs were either transfected alone or cotransfected. All clones overexpressing MT1-MMP 1) were able to activate endogenous or exogenous pro-MMP-2, 2) displayed an enhanced in vitro invasiveness through matrigel-coated filters independent of MMP-2 transfection, 3) induced the rapid development of highly vascularized tumors when injected subcutaneously in nude mice, and 4) promoted blood vessels sprouting in the rat aortic ring assay. These effects were observed in all clones overexpressing MT1-MMP regardless of MMP-2 expression levels, suggesting that the production of MMP-2 by tumor cells themselves does not play a critical role in these events. The angiogenic phenotype of MT1-MMP-producing cells was associated with an up-regulation of VEGF expression. These results emphasize the importance of MT1-MMP during tumor ang...Continue Reading

References

Mar 1, 1980·Analytical Biochemistry·C Labarca, K Paigen
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·A OkadaP Basset
Oct 1, 1994·Pathology, Research and Practice·A NoëlJ M Foidart
Aug 1, 1993·Journal of Cellular Physiology·H W SchnaperD L French
Jan 17, 1996·International Journal of Cancer. Journal International Du Cancer·C GillesJ M Foidart
Apr 1, 1996·Virchows Archiv : an International Journal of Pathology·M PoletteP Birembaut
Jan 1, 1997·Annual Review of Physiology·H A ChapmanG P Shi
Jun 20, 1997·International Journal of Cancer. Journal International Du Cancer·M MoriT Akiyoshi
Aug 7, 1997·International Journal of Cancer. Journal International Du Cancer·B NawrockiP Birembaut
May 4, 1999·The Journal of Clinical Investigation·W G Stetler-Stevenson
Feb 9, 2000·The Journal of Cell Biology·N KoshikawaV Quaranta
Mar 23, 2000·International Journal of Cancer. Journal International Du Cancer·E I DeryuginaA Y Strongin
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·Z ZhouK Tryggvason
Mar 31, 2000·Molecular Medicine Today·L J McCawley, L M Matrisian
Apr 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·J FangM A Moses
Oct 12, 2000·Nature Cell Biology·G BergersD Hanahan
Jan 25, 2002·Angiogenesis·S BlacherJ M Foidart

❮ Previous
Next ❯

Citations

May 16, 2006·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Mingfu WuDing Ma
Oct 27, 2007·Cancer Immunology, Immunotherapy : CII·David C DeRosaRobert J Benschop
Sep 18, 2004·Histochemistry and Cell Biology·Francesco GirolamoLuisa Roncali
Oct 8, 2005·Angiogenesis·Charlotta Dabrosin
Oct 19, 2013·Bulletin of Experimental Biology and Medicine·A M ScherbakovN E Kushlinskii
Oct 31, 2007·Clinical & Experimental Metastasis·Vincent Chabottaux, Agnès Noel
May 8, 2010·Journal of Mammary Gland Biology and Neoplasia·Arnaud BonnometChristine Gilles
Jan 12, 2010·Journal of Neuro-oncology·Yang LiuKevin A Walter
Feb 27, 2004·Biochimica Et Biophysica Acta·Aernout LuttunPeter Carmeliet
Apr 26, 2003·Matrix Biology : Journal of the International Society for Matrix Biology·N E SounniA Noel
Mar 20, 2003·Mutation Research·Sheau-Fung ThaiJames C Fuscoe
Dec 24, 2011·Nature Protocols·Marianne BakerKairbaan Hodivala-Dilke
Jun 28, 2011·Nature Reviews. Cancer·Denis WirtzPeter C Searson
Jul 29, 2011·The Journal of Biological Chemistry·Kevin ZarrabiJian Cao
Dec 13, 2012·Molecular & Cellular Proteomics : MCP·Stefan TholenOliver Schilling
Jan 8, 2008·Molecular Human Reproduction·Margreet PlaisierVictor W M van Hinsbergh
Apr 27, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Charlotte SelvaisHervé Emonard
May 29, 2004·Journal of Clinical Pathology·A NoelJ M Foidart
Feb 26, 2008·Investigative Ophthalmology & Visual Science·Hyeong Gon YuIvana K Kim
Jun 17, 2006·Breast Cancer Research : BCR·Bernard TêtuDominique Trudel
Mar 13, 2010·Disease Models & Mechanisms·Nor E SounniLisa M Coussens
May 8, 2003·Biological Procedures Online·V éRonique Masson VAgnès Noël
Jan 1, 2014·Laboratory Investigation; a Journal of Technical Methods and Pathology·Ju-Hyun GongYoung-Hee Kang
Jul 31, 2010·Journal of Oncology·N E CampbellJ Petrik
Mar 14, 2009·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Huiyan ZhangJianguang Lu
Jan 7, 2011·Integrative Biology : Quantitative Biosciences From Nano to Macro·Amit Pathak, Sanjay Kumar
Oct 20, 2006·Critical Reviews in Clinical Laboratory Sciences·Edgardo V AriztiaDavid A Fishman
Jan 30, 2013·Biochemical and Biophysical Research Communications·Ju Hee LeeJeong-Heon Ko

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.