MTA1, a transcriptional activator of breast cancer amplified sequence 3.

Proceedings of the National Academy of Sciences of the United States of America
Anupama E GururajRakesh Kumar

Abstract

Here we define a function of metastasis-associated protein 1 (MTA1), a presumed corepressor of estrogen receptor alpha (ERalpha), as a transcriptional activator of Breast Cancer Amplified Sequence 3 (BCAS3), a gene amplified and overexpressed in breast cancers. We identified BCAS3 as a MTA1 chromatin target in a functional genomic screen. MTA1 stimulation of BCAS3 transcription required ERalpha and involved a functional ERE half-site in BCAS3. Furthermore, we discovered that MTA1 is acetylated on lysine 626, and that this acetylation is necessary for a productive transcriptional recruitment of RNA polymerase II complex to the BCAS3 enhancer sequence. BCAS3 expression was elevated in mammary tumors from MTA1 transgenic mice and 60% of the human breast tumors, and correlated with the coexpression of MTA1 as well as with tumor grade and proliferation of primary breast tumor samples. These findings reveal a previously unrecognized function of MTA1 in stimulating BCAS3 expression and suggest an important role for MTA1-BCAS3 pathway in promoting cancerous phenotypes in breast tumor cells.

References

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Citations

Jun 6, 2007·Journal of Mammary Gland Biology and Neoplasia·Rajesh R Singh, Rakesh Kumar
Sep 27, 2006·Pituitary·Eva Hofsli
May 31, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiao-yun MaoFeng Jin
Jul 8, 2011·Nature Reviews. Cancer·Anne Y Lai, Paul A Wade
Jan 11, 2011·Oncogene·M P WalkerG L Greene
Jul 14, 2010·Médecine sciences : M/S·Coralie PoulardMuriel Le Romancer
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Da-Qiang LiRakesh Kumar
May 11, 2011·Proceedings of the National Academy of Sciences of the United States of America·Da-Qiang LiRakesh Kumar
Mar 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sirigiri Divijendra Natha ReddyRakesh Kumar
Dec 22, 2009·The Journal of Biological Chemistry·Tri M Bui-NguyenRakesh Kumar
Apr 30, 2010·The Journal of Biological Chemistry·Da-Qiang LiRakesh Kumar
Aug 13, 2010·The Journal of Biological Chemistry·Suresh B PakalaRakesh Kumar
Oct 22, 2009·Cancer Research·Bert W O'Malley, Rakesh Kumar
Feb 26, 2010·Molecular Endocrinology·Rainer B LanzBert W O'Malley
Mar 3, 2011·PloS One·Krishna Sumanth GhantaRakesh Kumar
Nov 10, 2013·Journal of Molecular Endocrinology·Christopher J MillardJohn W R Schwabe
Mar 31, 2011·World Journal of Gastroenterology : WJG·Bin DuXu-Long Zhou
Mar 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Qingchang MengRakesh Kumar
Nov 16, 2014·Cancer Metastasis Reviews·Jian LiuHaili Qian
Oct 22, 2014·Cancer Metastasis Reviews·Anait S LevensonXu Zhang
Oct 27, 2014·Cancer Metastasis Reviews·Nirmalya SenRakesh Kumar
Nov 7, 2014·Cancer Metastasis Reviews·Ekjot KaurShilpee Dutt
Oct 22, 2014·Cancer Metastasis Reviews·Yun Zhang, Xiao-Fan Wang
Apr 14, 2010·Expert Opinion on Investigational Drugs·Kazufumi Ohshiro, Rakesh Kumar
Feb 13, 2016·Gene·Rakesh Kumar, Rui-An Wang
Dec 23, 2015·Journal of Experimental & Clinical Cancer Research : CR·Caihua XuZhenya Shen
Nov 21, 2008·Trends in Endocrinology and Metabolism : TEM·Sang Jun HanBert W O'Malley
Jul 17, 2010·American Journal of Medical Genetics. Part a·Francesca Clementina RadioBruno Dallapiccola
Nov 19, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Emma E M KnowlesDavid C Glahn
Mar 24, 2016·Cellular Oncology (Dordrecht)·Angelo Ferraro

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