MTA1 drives malignant progression and bone metastasis in prostate cancer

Molecular Oncology
Avinash KumarAnait S Levenson

Abstract

Prostate cancer often metastasizes to the bone, leading to morbidity and mortality. While metastasis-associated protein 1 (MTA1) is highly overexpressed in metastatic tumors and bone metastatic lesions, its exact role in the development of metastasis is unknown. Here, we report the role of MTA1 in prostate cancer progression and bone metastasis in vitro and in vivo. We found that MTA1 silencing diminished formation of bone metastases and impaired tumor growth in intracardiac and subcutaneous prostate cancer xenografts, respectively. This was attributed to reduced colony formation, invasion, and migration capabilities of MTA1 knockdown cells. Mechanistic studies revealed that MTA1 silencing led to a significant decrease in the expression of cathepsin B (CTSB), a cysteine protease critical for bone metastasis, with an expected increase in the levels of E-cadherin in both cells and xenograft tumors. Moreover, meta-analysis of clinical samples indicated a positive correlation between MTA1 and CTSB. Together, these results demonstrate the critical role of MTA1 as an upstream regulator of CTSB-mediated events associated with cell invasiveness and raise the possibility that targeting MTA1/CTSB signaling in the tumor may prevent the de...Continue Reading

References

Mar 3, 2001·Neoplasia : an International Journal for Oncology Research·A RehemtullaB D Ross
Mar 27, 2004·Cancer Treatment and Research·Thomas J RosolLaurie K McCauley
Apr 1, 2005·Neoplasia : an International Journal for Oncology Research·Izabela PodgorskiBonnie F Sloane
Jul 13, 2006·Archives of Pathology & Laboratory Medicine·Matthias D HoferMark A Rubin
Oct 8, 2009·International Journal of Cancer. Journal International Du Cancer·Li KaiAnait S Levenson
Jan 24, 2012·Cancer Research·Nimali P WithanaBelinda S Parker
Feb 19, 2014·Biomaterials·Boris M HolzapfelDietmar W Hutmacher
May 30, 2014·The American Journal of Clinical Nutrition·Janet M PaveseRaymond C Bergan
Oct 22, 2014·Cancer Metastasis Reviews·Anait S LevensonXu Zhang
Jan 13, 2015·Advanced Drug Delivery Reviews·Mark Chong Seow Khoon
Jul 28, 2015·Annals of the New York Academy of Sciences·Avinash KumarAnait S Levenson

❮ Previous
Next ❯

Citations

Sep 7, 2019·Nutrients·Avinash KumarAnait S Levenson
Jul 31, 2020·Journal of Experimental & Clinical Cancer Research : CR·Shi-Jie WangZhi-Nan Chen
May 16, 2020·Oxidative Medicine and Cellular Longevity·Caroline N BarquilhaSérgio L Felisbino
Dec 2, 2020·Nutrients·Ketaki GadkariAnait S Levenson
Jan 14, 2021·International Journal of Molecular Sciences·Han Yeoung LeeJong Kook Park
Feb 24, 2019·Cancer Letters·Olja MijanovićMaciej S Lesniak
Jun 1, 2021·Cancer Biomarkers : Section a of Disease Markers·Xiang MaLi Yang

❮ Previous
Next ❯

Methods Mentioned

BETA
immunoprecipitation
xenografts
transgenic
xenograft
biopsies
Biopsy
bioluminescence
Ch

Software Mentioned

graphpad prism
GraphPad
imagetool
imagej
Infinity Analyze

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Related Papers

Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban
Yumei RaoGang Chen
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Seda Tuncay CagataySreeparna Banerjee
© 2022 Meta ULC. All rights reserved