MTBVAC vaccine is safe, immunogenic and confers protective efficacy against Mycobacterium tuberculosis in newborn mice

Tuberculosis
Nacho AguiloCarlos Martin

Abstract

Development of novel more efficient preventive vaccines against tuberculosis (TB) is crucial to achieve TB eradication by 2050, one of the Millennium Development Goals (MDG) for the current century. MTBVAC is the first and only live attenuated vaccine based on a human isolate of Mycobacterium tuberculosis developed as BCG-replacement strategy in newborns that has entered first-in-human adult clinical trials. In this work, we characterize the safety, immunogenicity and protective efficacy of MTBVAC in a model of newborn C57/BL6 mice. Our data clearly indicate that MTBVAC is safe for newborn mice, and does not affect animal growth or organ development. In addition, MTBVAC-vaccinated mice at birth showed enhanced immunogenicity and better protection against M. tuberculosis challenge in comparison with BCG.

References

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Citations

May 10, 2016·Tuberculosis·Aliabbas A HusainRajpal S Kashyap
Jun 2, 2016·The Journal of Infectious Diseases·Thomas J ScribaOlivier Neyrolles
Apr 28, 2017·Expert Review of Vaccines·Dessislava MarinovaCarlos Martin
Sep 21, 2017·Expert Opinion on Biological Therapy·Roberto Zenteno-Cuevas
Mar 7, 2018·Advanced Healthcare Materials·Leon Chien-Wei LinChe-Ming Jack Hu
Nov 27, 2018·Current Molecular Pharmacology·Manaf AlMatarFatih Köksal
May 6, 2019·Scandinavian Journal of Immunology·Patricia Méndez-Samperio
Jun 4, 2019·Human Vaccines & Immunotherapeutics·Federico Martinón-TorresRobb Butler
Jun 19, 2020·Pathogens·Ana BalseiroMaría A Risalde
Feb 16, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Junli LiChuan Qin
Sep 29, 2020·Applied Biochemistry and Microbiology·N I NadolinskaiaA V Goncharenko
Oct 22, 2020·NPJ Vaccines·Riti Sharan, Deepak Kaushal
Mar 27, 2021·Human Vaccines & Immunotherapeutics·Thomas ChoVishwanath Venketaraman
Jul 13, 2019·Microbiology Spectrum·Jonathan Kevin Sia, Jyothi Rengarajan
Jul 16, 2017·Microbiology Spectrum·Jesus Gonzalo-AsensioCarlos Martin
Dec 15, 2020·ACS Biomaterials Science & Engineering·Lampouguin Yenkoidiok-Douti, Christopher M Jewell
Jul 10, 2021·Vaccine·Carlos MartínJesús Gonzalo-Asensio

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Methods Mentioned

BETA
ELISA

Clinical Trials Mentioned

NCT02013245

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