MTH1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides

DNA Repair
Y NakabeppuDaisuke Tsuchimoto

Abstract

In human and rodent cells, MTH1, an oxidized purine nucleoside triphosphatase, efficiently hydrolyzes oxidized dGTP, GTP, dATP and ATP such as 2'-deoxy-8-oxoguanosine triphosphate (8-oxo-dGTP) and 2'-deoxy-2-hydroxyadenosine triphosphate (2-OH-dATP) in nucleotide pools, thus avoiding their incorporation into DNA or RNA. MTH1 is expressed in postmitotic neurons as well as in proliferative tissues, and it is localized both in the mitochondria and nucleus, thus suggesting that MTH1 plays an important role in the prevention of the mutagenicity and cytotoxicity of such oxidized purines as 8-oxoG which are known to accumulate in the cellular genome. Our recent studies with MTH1-deficient mice or cells revealed that MTH1 efficiently minimizes accumulation of 8-oxoG in both nuclear and mitochondrial DNA in the mouse brain as well as in cultured cells, thus contributing to the protection of the brain from oxidative stress.

References

Nov 1, 1992·Journal of Neurochemistry·B Halliwell
Jan 1, 1991·Free Radical Research Communications·L R KaramM G Simic
Oct 29, 1993·Science·J T Coyle, P Puttfarcken
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·M K ShigenagaB N Ames
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B N AmesT M Hagen
Nov 10, 1995·Neuroscience Letters·A H WaterfallC A Marsden
Aug 15, 1998·Biochemical and Biophysical Research Communications·Y MitsumotoN Koga
Mar 26, 1999·Biochemistry·H HayakawaM Sekiguchi
Apr 8, 1999·Experimental Neurology·I Kurkowska-JastrzebskaA Członkowska
Apr 25, 2000·Archives of Biochemistry and Biophysics·S Boiteux, J P Radicella
Jan 5, 2002·Journal of Neural Transmission·N Schmidt, B Ferger
Dec 4, 2002·Nature Reviews. Neuroscience·Julie Lotharius, Patrik Brundin
Feb 4, 2003·Radiology·Jeffrey R PetrellaP Murali Doraiswamy
Mar 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Joan Selverstone Valentine, P John Hart
Apr 18, 2003·Neuroscience·M Patel, Q Y Li
Jul 2, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marcus S CookeJoseph Lunec
Jul 15, 2003·The Journal of Biological Chemistry·Daisuke YoshimuraYusaku Nakabeppu
Aug 10, 2004·Nature Medicine·Julie K Andersen
Oct 30, 2004·Nature Genetics·Alan F WrightRudolph A Riemersma
Jun 15, 2005·Molecular Neurobiology·Qun WangAlbert Y Sun
Nov 5, 2005·Brain Research. Brain Research Reviews·P Hemachandra Reddy, M Flint Beal
Apr 12, 2006·Biological Chemistry·Yusaku NakabeppuYoshimichi Nakatsu

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Citations

Mar 10, 2009·Acta Neuropathologica·Akihiko NunomuraGeorge Perry
Jan 15, 2011·Journal of Molecular Neuroscience : MN·Eiji IwamaYusaku Nakabeppu
Jun 7, 2012·Neurotoxicity Research·Akihiko NunomuraGeorge Perry
Jul 24, 2010·Antioxidants & Redox Signaling·David SvilarRobert W Sobol
Mar 28, 2012·Nihon eiseigaku zasshi. Japanese journal of hygiene·Yuki OgasawaraKazuyuki Ishii
Mar 28, 2009·International Journal of Molecular Sciences·Rudy J CastellaniMark A Smith
Jun 16, 2014·Journal of Molecular Graphics & Modelling·Shin-Ichi FujiwaraTakashi Amisaki
Nov 28, 2012·Cellular and Molecular Life Sciences : CMLS·Alexander G McLennan
Jul 27, 2011·FEBS Letters·Linda M SvenssonPål Stenmark
May 23, 2012·Free Radical Biology & Medicine·Clementina MesarosIan A Blair
Jun 15, 2010·Mutation Research·Daisuke TsuchimotoYusaku Nakabeppu
Apr 20, 2010·DNA Repair·Barbara van LoonUlrich Hübscher
Nov 29, 2015·Cancer Chemotherapy and Pharmacology·Chiara RampazzoLars Petter Jordheim
Jan 1, 2014·Wiley Interdisciplinary Reviews. RNA·Zhongwei LiJames M Li
Mar 11, 2015·Journal of Cellular Biochemistry·Aishwarya Prakash, Sylvie Doublié
Aug 25, 2015·Nature Reviews. Cancer·Christopher K Mathews
Feb 9, 2008·Free Radical Biology & Medicine·Paula I MoreiraGeorge Perry
Oct 6, 2007·European Neurology·Gaofeng JiangChangcai Zhu
Apr 5, 2017·Acta Crystallographica. Section D, Structural Biology·S M ArifM Vijayan
Jun 28, 2017·Parasitology·Anna Cláudia Guimarães FreireCarlos Renato Machado
Nov 17, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Yuchen ShenWuliji Saiyin
Feb 7, 2007·Journal of Neuroscience Research·Yusaku NakabeppuKunihiko Sakumi
Jun 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Karolina BoguszewskaBolesław T Karwowski
Oct 28, 2017·Cancer Cell International·Jingjing DuanYi Ba
Jun 21, 2013·PLoS Neglected Tropical Diseases·Pedro H N AguiarCarlos R Machado
Mar 25, 2009·Chemical Research in Toxicology·Dipti MangalIan A Blair
Oct 6, 2020·Aging and Disease·Xinmu Zhang, Lin Li

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