MTHFR 677C>T polymorphism increases the male infertility risk: a meta-analysis involving 26 studies

PloS One
Mancheng GongRunqiang Yuan

Abstract

Methylenetetrahydrofolate reductase (MTHFR) polymorphism may be a risk factor for male infertility. However, the epidemiologic studies showed inconsistent results regarding MTHFR polymorphism and the risk of male infertility. Therefore, we performed a meta-analysis of published case-control studies to re-examine the controversy. Electronic searches of PubMed, EMBASE, Google Scholar and China National Knowledge Infrastructure (CNKI) were conducted to select eligible literatures for this meta-analysis (updated to June 19, 2014). According to our inclusion criteria and the Newcastle-Ottawa Scale (NOS), only high quality studies that observed the association between MTHFR polymorphism and male infertility risk were included. Crude odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of association between the MTHFR polymorphism and male infertility risk. Twenty-six studies involving 5,575 cases and 5,447 controls were recruited. Overall, MTHFR 677C>T polymorphism showed significant associations with male infertility risk in both fixed effects (CT+TT vs. CC: OR = 1.34, 95% CI: 1.23-1.46) and random effects models (CT+TT vs. CC: OR = 1.39, 95% CI: 1.19-1.62). Further, when stratified by ethnicity, sperm c...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Oct 1, 1993·Fertility and Sterility·G BentivoglioP Cristoforoni
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Nov 14, 1997·Medical Hypotheses·P W Parodi
May 23, 1998·American Journal of Human Genetics·J A SchneiderJ B Clegg
Jul 29, 1998·Mammalian Genome : Official Journal of the International Mammalian Genome Society·P GoyetteR Rozen
Apr 11, 2001·Endocrine Reviews·C ForestaA Ferlin
Apr 17, 2001·The New England Journal of Medicine·G BezoldR U Peter
Jul 14, 2001·Critical Reviews in Clinical Laboratory Sciences·J G Donnelly
Jul 27, 2001·The American Journal of Clinical Nutrition·A C Antony
Nov 16, 2001·Asia Pacific Journal of Clinical Nutrition·A V LakshmiT P Krishna
Jan 5, 2002·Human Reproduction·G R DohleL C P Govaerts
Mar 2, 2002·Fertility and Sterility·Wai Yee WongRégine P M Steegers-Theunissen
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Oct 25, 2003·European Journal of Clinical Nutrition·P PathakS N Dwivedi
Nov 5, 2003·Journal of Endocrinological Investigation·L StuppiaG Palka
Jul 10, 2004·Cell Death and Differentiation·R C AustinG H Werstuck
Sep 25, 2004·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Hülya YilmazTurgay Isbir
Dec 14, 2004·Genetic Epidemiology·Elias Zintzaras, John P A Ioannidis
Aug 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Claudio PelucchiCarlo La Vecchia
Oct 26, 2005·Journal of Assisted Reproduction and Genetics·Jung Hoon ParkSuman Lee
Dec 14, 2005·Current Topics in Developmental Biology·James A Maclean, Miles F Wilkinson
Feb 18, 2006·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·V ParacchiniE Taioli
May 3, 2006·Archives of General Psychiatry·Raymond L OwnbyDavid Loewenstein
Feb 3, 2007·American Journal of Human Genetics·Ping-I LinEden R Martin
Jun 21, 2007·Reproductive Biomedicine Online·Alberto FerlinCarlo Foresta
Jul 20, 2007·Human Molecular Genetics·Hisato KobayashiTakahiro Arima
Dec 8, 2007·Reproductive Biomedicine Online·Frank TüttelmannManuela Simoni
Dec 11, 2007·International Journal of Andrology·Jie LiangXinru Wang
Jan 12, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C PelucchiC La Vecchia
Oct 9, 2009·Nature·Teri A ManolioPeter M Visscher
Jan 28, 2010·Fertility and Sterility·Katherine L O'Flynn O'BrienAshok Agarwal

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Citations

Oct 9, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Csilla KrauszChiara Chianese
Sep 17, 2016·Journal of Reproductive Immunology·Shun ZhangZu-Yi Chen
Jul 16, 2016·Epigenomics·Habib A Shojaei SaadiClaude Robert
Nov 10, 2018·Annual Review of Animal Biosciences·Constance E ClareKevin D Sinclair
May 24, 2019·Journal of Assisted Reproduction and Genetics·Laetitia Jacquesson-FournolsYves Menezo
Apr 12, 2017·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Qiang ZhangNai-Jun Tang
May 14, 2020·Journal of Assisted Reproduction and Genetics·Jelena MilenkovicNovica Bojanic
Jun 9, 2018·Journal of Assisted Reproduction and Genetics·Edouard J ServyYves J R Menezo
Sep 12, 2020·Reproductive Biology and Endocrinology : RB&E·Fereshteh AliakbariFaezeh Azizi
Aug 27, 2017·Journal of Assisted Reproduction and Genetics·Dominique CornetYves Ménézo

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Methods Mentioned

BETA
chromosomal aberrations
genotyping

Software Mentioned

STATA
Google Scholar

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