PMID: 15354385Sep 10, 2004Paper

MTHFR C677T polymorphism, folic acid and hyperhomocysteinemia in levodopa treated patients with Parkinson's disease

Journal of Neural Transmission. Supplementum
D WoitallaT Müller

Abstract

Certain mutations (TT homozygous; CT heterozygous; CC wild-type) of the methylenetetrahydrofolate (MTHFR) gene and long-term levodopa application in patients with Parkinson's disease (PD) support onset of hyperhomocysteinemia. Total plasma homocysteine (t-hcys) depends on B6, B12, folic acid, all of which support remyelination from t-hcys to methionine. Objective of this trial were to compare B6, B12, folic acid and t-hcys levels in plasma of 83 levodopa treated PD patients and 44 controls. PD patients with the CT or TT genotype had significant higher t-hcys levels than controls or PD patients with the CC allele. Concentrations of B6 or B12 did not differ, but folic acid was significant higher in PD patients with the CT mutation. We recommend MTHFR genotyping, t-hcys monitoring and early vitamin supplementation in PD patients. The folic acid increase in PD patients with the CT allele is hypothetically due to an endogenous upregulation of folic acid absorption to decrease t-hcys.

Citations

May 9, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Thomas Müller, Wilfried Kuhn
Feb 24, 2017·Journal of Neural Transmission·Carsten BuhmannH Reichmann
Aug 17, 2006·Nutritional Neuroscience·Antonio SiniscalchiGiovambattista De Sarro
Aug 20, 2008·Food and Nutrition Bulletin·Irwin H Rosenberg
Mar 19, 2014·Acta Neurologica Scandinavica·Q LiaoR Peng
Oct 28, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Richard M CamicioliMartin J Somerville
May 20, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Maria C Rodriguez-OrozJose A Obeso

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