MTLE with hippocampal sclerosis in adult as a syndrome

Revue neurologique
M Baulac

Abstract

Mesial temporal lobe epilepsy with hippocampal sclerosis, (MTLE-HS) is a well characterized disorder which associates electroclinical features suggestive of seizure onset in the mesial or limbic structures of the temporal lobe, and hippocampal sclerosis. This underlying pathology differentiates MTLE-HS from MTLE due to other pathological substrates. Typically, when MTLE-HS is diagnosed, a typical course of the disease can be retrospectively recognized, including early prolonged febrile seizures, a latent period, onset in mid-to-late childhood, auras that may initially occur in isolation, periods of seizure remission during adolescence or early adulthood. Then the condition progresses, associating elaborated seizures, progressive drug-resistance and cognitive, mainly memory, disorders of variable intensity. The seizures have a relatively gradual onset/offset, developing over 1-2minutes, with partial awareness at the onset, and lasting for 2 to 10minutes. Auras are common, with visceral, autonomic, psycho-affective, experiential components, presenting less frequently diverse sensory or sensorial symptoms. Awareness is generally preserved at onset, but then loss of consciousness occurs, with initial motionless stare, and automatis...Continue Reading

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Citations

May 14, 2016·Epilepsy & Behavior : E&B·S M Jessica BehWendyl J D'Souza
Jan 25, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Julio RiquelmeChristian Bonansco
Feb 12, 2021·Biochemical and Biophysical Research Communications·Peng WangQipeng Zhang
Apr 20, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Rick Hgj van LanenKim Rijkers

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