mTOR, cardiomyocytes and inflammation in cardiac hypertrophy

Biochimica Et Biophysica Acta
Lifen Xu, Marijke Brink

Abstract

Mammalian target of rapamycin (mTOR) is an evolutionary conserved kinase that senses the nutrient and energy status of cells, the availability of growth factors, stress stimuli and other cellular and environmental cues. It responds by regulating a range of cellular processes related to metabolism and growth in accordance with the available resources and intracellular needs. mTOR has distinct functions depending on its assembly in the structurally distinct multiprotein complexes mTORC1 or mTORC2. Active mTORC1 enhances processes including glycolysis, protein, lipid and nucleotide biosynthesis, and it inhibits autophagy. Reported functions for mTORC2 after growth factor stimulation are very diverse, are tissue and cell-type specific, and include insulin-stimulated glucose transport and enhanced glycogen synthesis. In accordance with its cellular functions, mTOR has been demonstrated to regulate cardiac growth in response to pressure overload and is also known to regulate cells of the immune system. The present manuscript presents recently obtained insights into mechanisms whereby mTOR may change anabolic, catabolic and stress response pathways in cardiomocytes and discusses how mTOR may affect inflammatory cells in the heart duri...Continue Reading

References

Jul 26, 1990·The New England Journal of Medicine·B LevineM Packer
Nov 4, 1998·Journal of Molecular and Cellular Cardiology·A SimmJ Hoppe
Dec 10, 1999·The Journal of Clinical Investigation·F Liang, D G Gardner
Jul 11, 2001·Journal of Molecular and Cellular Cardiology·M Periasamy, S Huke
Mar 23, 2002·Molecular and Cellular Biology·Tetsuo ShioiSeigo Izumo
Apr 10, 2002·The Journal of Biological Chemistry·Yoshihiro IijimaDhandapani Kuppuswamy
Apr 2, 2003·Circulation·Tetsuo ShioiSeigo Izumo
Aug 13, 2003·Circulation·Nicole H Purcell, Jeffery D Molkentin
Jan 7, 2004·Nature Reviews. Drug Discovery·Michael KarinQ May Wang
May 15, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Yuehua LiChuanfu Li
Jul 14, 2004·The Journal of Cell Biology·Laura S HarringtonRichard F Lamb
Dec 21, 2004·Journal of the American College of Cardiology·Maike Krenz, Jeffrey Robbins
Jan 5, 2005·Biochemical and Biophysical Research Communications·Elangovan VellaichamyKailash N Pandey
Jan 5, 2005·Biochemical and Biophysical Research Communications·Kazunori KashiwaseKinya Otsu
Aug 3, 2005·The Journal of Clinical Investigation·Ichiro ShiojimaKenneth Walsh
Nov 22, 2005·Free Radical Biology & Medicine·Tuanzhu HaChuanfu Li
Feb 14, 2006·Cell·Stephan WullschlegerMichael N Hall
Apr 11, 2006·Molecular Cell·Dos D SarbassovDavid M Sabatini
Aug 1, 2006·Journal of Hypertension·Xiao-Ming GaoXiao-Jun Du
Dec 13, 2006·Circulation Research·Xuejun Wang, Jeffrey Robbins
Dec 22, 2006·Genes & Development·Ichiro Shiojima, Kenneth Walsh
Mar 31, 2007·Endocrinology·James A KuzmanA Martin Gerdes
May 2, 2007·Current Cardiology Reports·Arne YndestadPål Aukrust
Nov 3, 2007·Journal of Molecular and Cellular Cardiology·Phillip C MoschellaDhandapani Kuppuswamy
Oct 11, 2008·Journal of Molecular and Cellular Cardiology·Jeffery D Molkentin, Jeffrey Robbins
Nov 26, 2008·Histochemistry and Cell Biology·Ying XiaNikolaos G Frangogiannis

❮ Previous
Next ❯

Citations

May 19, 2016·Cell Biology International·Yufei YangAihua Chen
Jul 29, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Deise do Nascimento de FreitasAna Paula Duarte de Souza
Sep 19, 2016·Biochimica Et Biophysica Acta·Haipeng Sun, Yibin Wang
Jul 28, 2016·Cellular and Molecular Neurobiology·Fuxing DongYaping Liu
Jan 30, 2018·Annals of the New York Academy of Sciences·Peter C ReifsnyderRobert A Koza
Nov 2, 2017·PLoS Neglected Tropical Diseases·María Cristina VanrellPatricia Silvia Romano
Feb 7, 2019·Endocrinology·Danielle L BrooksGordon H Williams
Feb 12, 2019·British Journal of Pharmacology·Ling Yeong ChiaMasaaki Sato
Aug 31, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xianmin XuQiangrong Liang
May 26, 2020·Journal of Experimental & Clinical Cancer Research : CR·Xiaoping WangYong Wang
May 23, 2020·Journal of Cardiovascular Translational Research·Ahmed ElsanhourySophie Van Linthout
Aug 29, 2020·Journal of Biomedical Materials Research. Part a·Fujun ZhuYongming Yao
May 27, 2020·Oxidative Medicine and Cellular Longevity·Arthur José Pontes Oliveira de AlmeidaIsac Almeida de Medeiros
Jul 3, 2020·Frontiers in Physiology·J SnyderP Y Sato
May 22, 2019·Journal of Molecular Histology·Cheng FanHaipeng Guo
Oct 13, 2020·Current Opinion in Infectious Diseases·Mildred A Iro, Sudha Priya Soundara Pandi
Dec 29, 2020·Legal Medicine·Yu KakimotoMotoki Osawa
Dec 17, 2020·Frontiers in Cardiovascular Medicine·Zheng XiaoHe Huang
Mar 16, 2021·Frontiers in Endocrinology·Arkadiusz D LiśkiewiczJoanna Lewin-Kowalik
Dec 19, 2020·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Haitao YuanJing Geng
Mar 31, 2021·Current Hypertension Reports·Lokesh Kumar BhattTahir Hussain
Apr 4, 2021·International Journal of Molecular Sciences·Mojca LunderMišo Šabovič
Jul 23, 2018·Mechanisms of Ageing and Development·Paweł SmykiewiczTymoteusz Żera
Jul 27, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaomin KangFengmei Lian
Aug 1, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yuqian ZhaoXinsheng Yao
Aug 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jinhao TaoGangfeng Yan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Acta Biochimica Et Biophysica Sinica
Tsukasa Suzuki, Ken Inoki
Alcoholism, Clinical and Experimental Research
Ly Q Hong-BrownCharles H Lang
Current Opinion in Cell Biology
Pazit Polak, Michael N Hall
Cold Spring Harbor Perspectives in Biology
Chien-Min HungDavid A Guertin
© 2022 Meta ULC. All rights reserved