mTOR complex 2 is an integrator of cancer metabolism and epigenetics

Cancer Letters
Kenta MasuiNoriyuki Shibata

Abstract

Metabolic reprogramming is a central hallmark of cancer and is driven by abnormalites of oncogenes and tumor suppressors. This enables tumor cells to obtain the macromolecular precursors and energy needed for rapid tumor growth. Accelerated metabolism also translates into cancer cell aggression through epigenetic changes. The aberrant signaling cascades activated by oncogenes coordinate metabolic reprogramming with epigenetic shifts and subsequent global transcriptional changes through the dysregulation of rate-limiting metabolic enzymes as well as by facilitating the production of intermediary metabolites. As the landscape of cancer cell metabolism has been elucidated, it is now time for this knowledge to be translated into benefit for patients. Here we review the recently identified central regulatory role for mechanistic/mammalian target of rapamycin complex 2 (mTORC2), a downstream effector of many cancer-causing mutations, in reprogramming the metabolic and epigenetic landscape. This leads to tumor cell survival and cancer drug resistance.

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Citations

Jun 14, 2020·Genes·R Nicholas Laribee, Ronit Weisman
Jan 29, 2021·Phytotherapy Research : PTR·Milad AshrafizadehMasoud Najafi
Feb 7, 2021·Molecular Cancer·Longzheng XiaQianjin Liao
Mar 16, 2021·Frontiers in Bioengineering and Biotechnology·Delphine SéhédicEmmanuel Garcion
Mar 30, 2021·Oxidative Medicine and Cellular Longevity·Mingjing YanJian Li
Jul 20, 2021·Acta Histochemica Et Cytochemica·Hiromi OnizukaNoriyuki Shibata

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