mTOR controls kidney epithelia in health and disease

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Florian GrahammerTobias B Huber

Abstract

Renal epithelial function is the cornerstone of key excretory processes performed by our kidneys. Most of these tasks need to be tightly controlled to keep our internal environment in balance. Recently, the mTOR signalling network emerged as a key pathway controlling renal epithelial cells from the glomerular tuft along the entire nephron. Both mTOR complexes, mTORC1 and mTORC2, regulate such diverse processes as glomerular filtration and the fine tuning of tubular electrolyte balance. Most importantly, dysregulation of mTOR signalling contributes to prevalent kidney diseases like diabetic nephropathy and cystic kidney disease. The following review shall summarize our current knowledge of the renal epithelial mTOR signalling system under physiological and pathophysiological conditions.

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Citations

Jun 5, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Johannes Schlondorff
Apr 5, 2016·The Journal of Clinical Investigation·Florian GrahammerTobias B Huber
Jul 5, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Stéphanie De RechterDjalila Mekahli
Jun 15, 2016·Journal of the American Society of Nephrology : JASN·Florian GrahammerFranziska Theilig
Oct 21, 2016·Antioxidants & Redox Signaling·Stéphanie EidAssaad A Eid
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Jul 12, 2014·Journal of the American Society of Nephrology : JASN·Honghui WangMarilyn G Farquhar
Mar 9, 2017·Journal of the American Society of Nephrology : JASN·Stefan ZschiedrichTobias B Huber
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Sep 14, 2021·Physiology·Florian GrahammerFerruh Artunc
Sep 22, 2021·Antioxidants & Redox Signaling·Alaa Abou DaherAssaad A Eid
Oct 6, 2021·Journal of the American Society of Nephrology : JASN·Karl P SchlingmannJeroen H F de Baaij

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