PMID: 11915918Mar 28, 2002Paper

mTOR-dependent control of skeletal muscle protein synthesis

International Journal of Sport Nutrition and Exercise Metabolism
J C Lawrence

Abstract

Muscle mass is influenced by many factors including genetically programmed changes, hormonal state, level of activity, and disease processes. Ultimately, whether or not a muscle hypertrophies or atrophies is determined by a simple relationship between the rates of protein synthesis and degradation. When synthesis exceeds degradation, the muscle hypertrophies, and vice versa. In contrast to this simple relationship, the processes that control muscle protein synthesis and degradation are complex. Recently, significant progress has been made in understanding the biochemical mechanisms that control the rate of translation initiation, which is generally the limiting phase in protein synthesis.

Citations

Sep 16, 2005·American Journal of Physiology. Cell Physiology·Jos L J van der VeldenAnnemie M W J Schols
Jun 10, 2004·American Journal of Physiology. Endocrinology and Metabolism·Charles H Lang, Robert A Frost
Nov 26, 2009·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Scott R RichmondPhilip M Gallagher
Jun 19, 2003·American Journal of Physiology. Endocrinology and Metabolism·Christopher J LynchSusan M Hutson
Dec 15, 2005·American Journal of Physiology. Endocrinology and Metabolism·Ippei YamaokaFumiaki Yoshizawa
Apr 12, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Patrice Delafontaine, Makoto Akao
Sep 2, 2004·American Journal of Physiology. Endocrinology and Metabolism·Jamie I BaumDonald K Layman
May 17, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Yassine El HianiXian-Ping Dong
Aug 4, 2020·Annals of Geriatric Medicine and Research·Hak Chul Jang
May 25, 2010·Journal of Nutritional Science and Vitaminology·Akinobu ImotoEva Selldén
Apr 22, 2016·Diabetes & Metabolism Journal·Hak Chul Jang

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