mTOR-dependent transcriptional repression of Pdcd4 tumor suppressor in lung cancer cells

Biochimica Et Biophysica Acta
P N VikhrevaIgor V Korobko

Abstract

Programmed cell death 4 (Pdcd4) tumor suppressor is frequently lost in tumors of various origins including lung cancer, and its loss contributes to tumor progression. However molecular mechanisms underlying Pdcd4 suppression in lung cancer cells remain largely unexplored. Here we investigated molecular mechanisms of Pdcd4 suppression in lung cancer cells. Besides enhanced mTOR-dependent proteasomal degradation of Pdcd4 protein, we found that Pdcd4 transcription is negatively regulated by mTOR signaling, and localized cis-acting element in Pdcd4 promoter responsible for this effect. In conclusion, we described a novel molecular mechanism of Pdcd4 suppression in cancer cells consisting from mTOR signaling-dependent transcriptional repression of Pdcd4.

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Citations

Mar 16, 2012·Doklady. Biochemistry and Biophysics·P N VikhrevaI V Korobko
Sep 16, 2015·Cell Communication and Signaling : CCS·Bianca KloosKatharina F Kubatzky
Jun 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Muhammad Umar AliCao Jiang
Nov 27, 2019·Cancer·Hongyi ZhangLucia B Jilaveanu
Aug 31, 2017·Cell Cycle·Polina N VikhrevaIgor V Korobko
May 12, 2019·International Journal of Molecular Sciences·Sachiko MatsuhashiIwata Ozaki
Mar 7, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Yuan-Teng XuRong Zhang

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