mTOR inhibition, the second generation: ATP-competitive mTOR inhibitor initiates unexpected receptor tyrosine kinase-driven feedback loop

Cancer Discovery
Megan Keniry, Ramon Parsons

Abstract

mTOR inhibition with the ATP-competitive kinase inhibitor AZD8055 induces receptor tyrosine kinase-dependent feedback activation of AKT.

References

May 22, 2001·Molecular and Cellular Biology·L SimpsonR Parsons
Apr 23, 2009·Science Signaling·David A Guertin, David M Sabatini
Dec 16, 2010·Nature Reviews. Molecular Cell Biology·Roberto ZoncuDavid M Sabatini
Dec 6, 2011·Cancer Discovery·Vanessa S Rodrik-OutmezguineNeal Rosen

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Citations

Apr 8, 2014·International Journal of Cancer. Journal International Du Cancer·Si-Meng ChenLing-Hua Meng
Dec 19, 2013·Cancer Biology & Therapy·Mikhail V Blagosklonny

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