mTOR is involved in stroke-induced seizures and the anti-seizure effect of mild hypothermia.

Molecular Medicine Reports
Guo-Shuai YangDan Yu

Abstract

Stroke is considered an underlying etiology of the development of seizures. Stroke leads to glucose and oxygen deficiency in neurons, resulting in brain dysfunction and injury. Mild hypothermia is a therapeutic strategy to inhibit stroke‑induced seizures, which may be associated with the regulation of energy metabolism of the brain. Mammalian target of rapamycin (mTOR) signaling and solute carrier family 2, facilitated glucose transporter member (GLUT)‑1 are critical for energy metabolism. Furthermore, mTOR overactivation and GLUT‑1 deficiency are associated with genetically acquired seizures. It has been hypothesized that mTOR and GLUT‑1 may additionally be involved in seizures elicited by stroke. The present study established global cerebral ischemia (GCI) models of rats. Convulsive seizure behaviors frequently occurred during the first and the second days following GCI, which were accompanied with seizure discharge reflected in the EEG monitor. Expression of phosphor (p)‑mTOR and GLUT‑1 were upregulated in the cerebral cortex and hippocampus, as evidenced by immunohistochemistry and western blot analyses. Mild hypothermia and/or rapamycin (mTOR inhibitor) treatments reduced the number of epileptic attacks, seizure severity s...Continue Reading

References

Mar 11, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K KawaiI Klatzo
May 31, 2008·The American Journal of Pathology·Xiuyun JiangRaymond S Yeung
Mar 14, 2009·The Neurologist·Juan M PascualAntonio Gil-Nagel
Oct 3, 2009·The New England Journal of Medicine·Denis V AzzopardiUNKNOWN TOBY Study Group
Feb 5, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·W Dalton Dietrich, Helen M Bramlett
Mar 2, 2011·Age·Fudong LiuLouise D McCullough
Jun 28, 2011·Journal of Child Neurology·Mary J HarbertDonna M Ferriero
Jul 11, 2012·Neuroepidemiology·Gaetano ProcacciantiTommaso Sacquegna
Dec 12, 2012·Annals of Neurology·Raimondo D'AmbrosioMatthew D Smyth
Feb 27, 2013·The Cochrane Database of Systematic Reviews·Susan E JacobsPeter G Davis
Apr 27, 2013·Future Neurology·Michael Wong
Mar 29, 2014·Frontiers in Molecular Neuroscience·Candi L Lasarge, Steve C Danzer
Apr 1, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Lei CaoZheng-Li Di
May 7, 2015·Experimental Neurology·Chiping WuLiang Zhang
Jun 6, 2015·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Max AndresenMaximiliano Rovegno
Jun 18, 2015·Arquivos de neuro-psiquiatria·Telma M R AssisOsvaldo J M Nascimento
Jun 4, 2016·Epilepsy Research·Zhigang LeiZao C Xu
Nov 2, 2016·Journal of Cell Science·Dania C Liemburg-ApersWerner J H Koopman
Apr 2, 2017·Seizure : the Journal of the British Epilepsy Association·Maria StefanidouDaniel Friedman

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Citations

Mar 4, 2020·International Journal of Molecular Sciences·Fiona LimanaqiFrancesco Fornai

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