mTOR Signaling and Neural Stem Cells: The Tuberous Sclerosis Complex Model

International Journal of Molecular Sciences
Alice PolchiCarla Emiliani

Abstract

The mechanistic target of rapamycin (mTOR), a serine-threonine kinase, plays a pivotal role in regulating cell growth and proliferation. Notably, a great deal of evidence indicates that mTOR signaling is also crucial in controlling proliferation and differentiation of several stem cell compartments. Consequently, dysregulation of the mTOR pathway is often associated with a variety of disease, such as cancer and metabolic and genetic disorders. For instance, hyperactivation of mTORC1 in neural stem cells (NSCs) is associated with the insurgence of neurological manifestation characterizing tuberous sclerosis complex (TSC). In this review, we survey the recent contributions of TSC physiopathology studies to understand the role of mTOR signaling in both neurogenesis and tumorigenesis and discuss how these new insights can contribute to developing new therapeutic strategies for neurological diseases and cancer.

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Citations

Sep 29, 2020·Frontiers in Molecular Neuroscience·Perrine CastetsMarkus A Rüegg
Aug 1, 2020·Frontiers in Cell and Developmental Biology·Lisa M Julian, William L Stanford
May 22, 2020·Proceedings of the National Academy of Sciences of the United States of America·Shun-Yun ChengClaudio Punzo
Feb 28, 2021·Cellular and Molecular Neurobiology·Xu ZhouLili Cui

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Methods Mentioned

BETA
nuclear translocation
GTPases
GTPase
xenograft

Software Mentioned

Rapalink

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