mTOR signalling: jack-of-all-trades 1

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
Yassine El HianiXian-Ping Dong

Abstract

The mechanistic target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase that senses and integrates environmental information into cellular regulation and homeostasis. Accumulating evidence has suggested a master role of mTOR signalling in many fundamental aspects of cell biology and organismal development. mTOR deregulation is implicated in a broad range of pathological conditions, including diabetes, cancer, neurodegenerative diseases, myopathies, inflammatory, infectious, and autoimmune conditions. Here, we review recent advances in our knowledge of mTOR signalling in mammalian physiology. We also discuss the impact of mTOR alteration in human diseases and how targeting mTOR function can treat human diseases.

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Citations

Feb 20, 2020·International Journal of Molecular Sciences·Gustavo FerrínManuel De la Mata
Jul 9, 2020·Clinical & Experimental Ophthalmology·Anthony Yao, Peter van Wijngaarden
Mar 5, 2020·Reviews in Endocrine & Metabolic Disorders·Jacob Bar-Tana

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