mTORC signaling in hematopoiesis

International Journal of Hematology
Xiaomin WangWei-Ping Yuan

Abstract

mTOR is a serine/threonine (Ser/Thr) protein kinase that responds to multiple signals, including growth factors, amino acids, energy status, stress, and oxygen, regulates cell survival, cell growth, the cell cycle, and cell metabolism, and maintains homeostasis [1]. Increased or decreased mTORC1 activity can alter HSC function and cause hematological disorders [2, 3]. Therefore, a comprehensive knowledge of mTOR is critical to understanding how HSCs function and maintain homeostasis in the hematopoietic system. In this review, we summarize recent advances in the understanding of the mTOR signaling pathway and its roles in hematopoiesis and leukemia. We also discuss pharmacological approaches to manipulate mTOR activity.

References

Sep 1, 1993·Trends in Biochemical Sciences·J Kunz, M N Hall
Jan 13, 1995·The Journal of Biological Chemistry·C J SabersR T Abraham
Feb 3, 1995·The Journal of Biological Chemistry·E F BlommaartA J Meijer
May 16, 2003·Current Biology : CB·Stefanie S SchalmJohn Blenis
Jul 19, 2003·Genes & Development·Ken InokiKun-Liang Guan
Sep 6, 2003·Cancer Cell·James B BrugarolasWilliam G Kaelin
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Valerie I BrownStephan A Grupp
Jul 9, 2004·Cellular Signalling·Paul-Joseph Aspuria, Fuyuhiko Tamanoi
Jul 16, 2004·Molecular and Cellular Biology·Mirei MurakamiShinya Yamanaka
Sep 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Philippe P RouxJohn Blenis
Oct 7, 2004·Nature Cell Biology·Estela JacintoMichael N Hall
Nov 20, 2004·Blood·Christian RécherBernard Payrastre
Feb 19, 2005·Science·D D SarbassovDavid M Sabatini
Jun 29, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas E WitzigScott H Kaufmann
Apr 11, 2006·Molecular Cell·Dos D SarbassovDavid M Sabatini
Aug 19, 2006·Current Treatment Options in Oncology·Thomas E Witzig, Scott H Kaufmann
Sep 29, 2006·The New England Journal of Medicine·Peter B CrinoElizabeth Petri Henske
Mar 10, 2007·The Biochemical Journal·Simon J Cook, Simon J Morley
Mar 28, 2007·Molecular Cell·Yasemin SancakDavid M Sabatini
Apr 28, 2007·The Biochemical Journal·Laura R PearceDario R Alessi
Oct 9, 2008·Blood·Steven M KornblauGordon B Mills
Dec 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Boyi GanRonald A DePinho
Jan 20, 2009·The Journal of Biological Chemistry·Carson C ThoreenNathanael S Gray
Feb 13, 2009·PLoS Biology·Morris E FeldmanKevan M Shokat
Feb 28, 2009·Blood·Kathleen CullionMichelle A Kelliher
Apr 3, 2009·Nature Reviews. Molecular Cell Biology·Xiaoju Max Ma, John Blenis

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Citations

Apr 14, 2016·Journal of Hematology & Oncology·Yanan GaoWeiping Yuan
May 26, 2016·Genomics, Proteomics & Bioinformatics·Tangliang LiZhao-Qi Wang
May 1, 2019·Anti-cancer Agents in Medicinal Chemistry·Xinyu ShaoChunli Zhou
Nov 27, 2018·Current Stem Cell Research & Therapy·Xinliang ZhangRui Ma
Sep 19, 2019·Scientific Reports·Menglin XuZhengwu Cheng
May 21, 2017·Investigational New Drugs·Chongchong Wang, Li Cheng
Feb 24, 2019·Cells·Carolina SimioniLuca M Neri
Mar 2, 2021·European Journal of Pharmacology·Ayda Baghery Saghchy KhorasaniDavood Bashash
Apr 1, 2021·Journal, Genetic Engineering & Biotechnology·Noha Hamdy EltaweelKhalda S Amr
May 6, 2021·International Journal of Molecular Sciences·Francesco Fazi, Alessandro Fatica
Jun 15, 2021·Frontiers in Cell and Developmental Biology·Juan GaoXiaomin Wang
Sep 7, 2021·Frontiers in Cell and Developmental Biology·Hong LiJianming Wu

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