mTORC1 and ferroptosis: Regulatory mechanisms and therapeutic potential.

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Guang LeiBoyi Gan

Abstract

Ferroptosis, a form of regulated cell death triggered by lipid hydroperoxide accumulation, has an important role in a variety of diseases and pathological conditions, such as cancer. Targeting ferroptosis is emerging as a promising means of therapeutic intervention in cancer treatment. Polyunsaturated fatty acids, reactive oxygen species, and labile iron constitute the major underlying triggers for ferroptosis. Other regulators of ferroptosis have also been discovered recently, among them the mechanistic target of rapamycin complex 1 (mTORC1), a central controller of cell growth and metabolism. Inhibitors of mTORC1 have been used in treating diverse diseases, including cancer. In this review, we discuss recent findings linking mTORC1 to ferroptosis, dissect mechanisms underlying the establishment of mTORC1 as a key ferroptosis modulator, and highlight the potential of co-targeting mTORC1 and ferroptosis in cancer treatment. This review will provide valuable insights for future investigations of ferroptosis and mTORC1 in fundamental biology and cancer therapy.

References

Jul 21, 2004·Cancer Cell·Reuben J ShawLewis C Cantley
Jun 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Zhaohui FengShengkan Jin
Feb 14, 2006·Cell·Stephan WullschlegerMichael N Hall
Feb 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yan ZhengJonathan D Powell
Apr 29, 2008·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Bing-Hua Jiang, Ling-Zhi Liu
Sep 3, 2008·Cell Metabolism·Thomas PorstmannAlmut Schulze
Jan 20, 2009·The Journal of Biological Chemistry·Carson C ThoreenNathanael S Gray
Jun 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Eric OlmMikael Björnstedt
Jan 25, 2011·Nature Cell Biology·Joungmok KimKun-Liang Guan
Dec 6, 2011·Annual Review of Immunology·Jonathan D PowellMaureen R Horton
May 29, 2012·Cell·Scott J DixonBrent R Stockwell
May 21, 2013·Nature Cell Biology·Ryan C RussellKun-Liang Guan
Aug 15, 2013·Brain Pathology·Avanita S PrabowoEleonora Aronica
Jan 21, 2014·Cell·Wan Seok YangBrent R Stockwell
Nov 18, 2014·Nature Cell Biology·Jose Pedro Friedmann AngeliMarcus Conrad
Mar 24, 2015·The Journal of Clinical Investigation·Kazuhiro TanakaEiji Kohmura
May 7, 2015·Oncotarget·Ashley M HolderFunda Meric-Bernstam
May 13, 2015·ACS Chemical Biology·Scott J DixonBrent R Stockwell
Jul 15, 2015·Molecular Cell·Minghui GaoXuejun Jiang
Sep 26, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xiaofang SunDaolin Tang
Mar 26, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xiaofang SunDaolin Tang
May 18, 2016·Neurobiology of Disease·Bruce Do VanJean-Christophe Devedjian
Jun 2, 2016·Autophagy·Wen HouDaolin Tang
Aug 16, 2016·Cell Research·Minghui GaoXuejun Jiang
Nov 15, 2016·Nature Chemical Biology·Valerian E KaganHülya Bayır
Nov 15, 2016·Nature Chemical Biology·Sebastian DollMarcus Conrad
Mar 12, 2017·Cell·Robert A Saxton, David M Sabatini
Apr 16, 2017·Current Opinion in Cell Biology·Issam Ben-Sahra, Brendan D Manning
May 19, 2017·American Journal of Physiology. Renal Physiology·Oreoluwa AdedoyinAnupam Agarwal
May 23, 2017·Cancer Cell·Yiqun ZhangChad J Creighton
Jul 6, 2017·Nature·Vasanthi S ViswanathanStuart L Schreiber
Aug 30, 2017·Nature Reviews. Endocrinology·Hitoshi Shimano, Ryuichiro Sato
Nov 2, 2017·Nature·Matthew J HangauerMichael T McManus
Nov 12, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Yuichi BabaTakashi Matsui
Mar 10, 2018·Free Radical Biology & Medicine·José Pedro Friedmann Angeli, Marcus Conrad
Apr 6, 2018·Nature Reviews. Molecular Cell Biology·Ivan Dikic, Zvulun Elazar
May 26, 2018·PLoS Biology·Huizhong Feng, Brent R Stockwell

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