mTOR'ing across the Cortex by Chopping the Cilia

Neuron
Alessia Di Nardo, Mustafa Sahin

Abstract

Somatic mutation of the MTOR gene is a genetic etiology of focal malformations of cortical development. In this issue of Neuron, Park et al. (2018) identify defective autophagy-dependent ciliogenesis/Wnt signaling as an underlying mechanism affecting neuronal migration and cortical lamination.

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