MTSS1 and SCAMP1 cooperate to prevent invasion in breast cancer

Cell Death & Disease
Jayakumar VadakekolathuT Regad

Abstract

Cell-cell adhesions constitute the structural "glue" that retains cells together and contributes to tissue organisation and physiological function. The integrity of these structures is regulated by extracellular and intracellular signals and pathways that act on the functional units of cell adhesion such as the cell adhesion molecules/adhesion receptors, the extracellular matrix (ECM) proteins and the cytoplasmic plaque/peripheral membrane proteins. In advanced cancer, these regulatory pathways are dysregulated and lead to cell-cell adhesion disassembly, increased invasion and metastasis. The Metastasis suppressor protein 1 (MTSS1) plays a key role in the maintenance of cell-cell adhesions and its loss correlates with tumour progression in a variety of cancers. However, the mechanisms that regulate its function are not well-known. Using a system biology approach, we unravelled potential interacting partners of MTSS1. We found that the secretory carrier-associated membrane protein 1 (SCAMP1), a molecule involved in post-Golgi recycling pathways and in endosome cell membrane recycling, enhances Mtss1 anti-invasive function in HER2+/ER-/PR- breast cancer, by promoting its protein trafficking leading to elevated levels of RAC1-GTP ...Continue Reading

References

Dec 21, 2000·Current Oncology Reports·S SundaresanM X Sliwkowski
Feb 12, 2004·Cancer Research·Matthias D HoferMark A Rubin
Jul 27, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lisa M McShaneUNKNOWN Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics
Sep 23, 2006·Nature Reviews. Cancer·Mona Mostafa Mohamed, Bonnie F Sloane
Nov 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David G HicksGraham Casey
May 15, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Laura M Machesky, Simon A Johnston
Mar 31, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Christian Parr, Wen G Jiang
Dec 5, 2009·The Journal of Biological Chemistry·Wayne J HigginsD Margaret Worrall
Jun 10, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ricardo H AlvarezGabriel N Hortobagyi
Jan 5, 2011·Frontiers in Bioscience (Scholar Edition)·Fei XieWen G Jiang
Jun 3, 2011·Protoplasma·Angus Ho Yin LawLiwen Jiang
Oct 13, 2011·The Journal of Pathology·Matthew A BrookeDavid P Kelsell
Mar 19, 2014·Nature Communications·Kirsten D MertzStephan N Wagner
Mar 29, 2014·British Journal of Pharmacology·C M FifeM Kavallaris
Aug 2, 2014·Nature Cell Biology·Sandra S McAllister, Robert A Weinberg
Nov 12, 2014·Biochemistry. Biokhimii︠a︡·A Y Alexandrova
Nov 12, 2014·Journal of Neuro-oncology·Shoudan Zhang, Qigui Qi
Apr 14, 2015·Seminars in Cancer Biology·W G JiangD Santini
Dec 2, 2015·Leukemia·M SchemionekS Koschmieder
Apr 30, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ingrid A MayerCarlos L Arteaga
Jul 26, 2016·Experimental and Therapeutic Medicine·Dong-Jin LingTa-Yao Yin
Feb 2, 2017·Oncotarget·Ann E ZeleniakReginald Hill

❮ Previous
Next ❯

Citations

Jan 29, 2020·The Pharmacogenomics Journal·Tingting QianLin Fu
May 24, 2019·Journal of Experimental & Clinical Cancer Research : CR·Shaymaa Ik Al-JubooriTarik Regad
Aug 25, 2021·Scientific Reports·Can YueYiming Luo
Sep 29, 2020·Analytical Chemistry·Christopher J BrownMilos V Novotny

❮ Previous
Next ❯

Methods Mentioned

BETA
proximity
immunoprecipitation
transfection
pull down
Assay
transfections
electrophoresis

Software Mentioned

SPSS
Carl Zeiss AxioVision

Related Concepts

Related Feeds

Breast Cancer Triple-N

Breast cancer cells have receptors for estrogen, progesterone, HER2 receptors (also called ERBB2). Triple-negative breast cancers do not have any of these receptors. Here are the latest discoveries pertaining to triple-negative breast cancers.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Related Papers

Journal of Gastroenterology and Hepatology
Judy Wai Ping YamIrene Oi-Lin Ng
Journal of Mammary Gland Biology and Neoplasia
Franziska SchatzmannCharles H Streuli
© 2022 Meta ULC. All rights reserved