PMID: 8945732Nov 1, 1996Paper

mu- and kappa-opioids inhibit K+ evoked glutamate release from rat cerebrocortical slices

Neuroscience Letters
B NicolD G Lambert

Abstract

We have examined the effects of a range of opioid receptor subtype selective agonists on K+ evoked glutamate release from perfused rat cerebrocortical slices. Dual application (S1 and S2) of K+ (46 mM) evoked dual monophasic glutamate release profiles. When areas under the release curves were calculated an S2/S1 ratio for control slices of 1.07 +/- 0.08 (n = 75) was obtained, this was reduced by 80% with EGTA (0.1 mM) treatment confirming the presence of a Ca2+ regulated release process, Morphine produced a dose-dependent inhibition of the S2/S1 ratio. At 1 microM this amounted to 78 +/- 12% (mean +/- SEM; n = 6). (D-Ala2,MePhe4,gly(ol)5)enkephalin (DAMGO; 60 +/- 12%, n = 6 at 1 microM), and spiradoline (53 +/- 14% at 1 and 71 +/- 11% at 100 microM, both n = 6) also inhibited glutamate release in a cyprodime (10 microM) and norbinaltorphimine (10 microM) reversible manner. (D-Pen2.5) enkephalin (DPDPE; 1 microM) was ineffective. All agents tested did not affect basal glutamate release. Collectively these data implicate a role for mu and kappa opioids in the control of evoked glutamate release and their potential for neuroprotective therapy.

References

Jul 1, 1988·Trends in Neurosciences·A MansourS J Watson
Feb 1, 1993·Clinical Neuropharmacology·G W Pasternak
Jul 25, 1995·European Journal of Pharmacology·M P Hill, J M Brotchie

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Citations

Apr 29, 1998·Brain Research. Developmental Brain Research·R A Code, A E McDaniel
Jul 3, 2003·Molecular and Cellular Neurosciences·Anders I PerssonPeter S Eriksson
Dec 21, 2002·Addiction·Francesco LeriJane Stewart
Jun 27, 2013·BioMed Research International·Adele L BoskeyJoan C Marini
Sep 18, 2007·Pharmacology & Therapeutics·T S ShippenbergV I Chefer
Feb 3, 2015·Experimental Physiology·Aline FassiniFernando M A Corrêa
Aug 21, 2007·Biochemical Pharmacology·Justin T Gass, M Foster Olive
Mar 28, 1998·Japanese Journal of Pharmacology·H ZhuI K Ho
Feb 8, 2006·Brain Research·Eddy Viard, Hreday N Sapru
Feb 4, 1999·Critical Care Clinics·A J Macfadyen, M A Buckmaster
May 13, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Susan M FergusonTerry E Robinson

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