Mu-opioid receptor is located on the plasma membrane of dendrites that receive asymmetric synapses from axon terminals containing leucine-enkephalin in the rat nucleus locus coeruleus

The Journal of Comparative Neurology
E J Van BockstaeleG R Uhl

Abstract

We have recently shown, by using immunoelectron microscopy, that the mu-opioid receptor (mu OR) is prominently distributed within noradrenergic perikarya and dendrites of the nucleus locus coeruleus (LC), many of which receive excitatory-type (i.e., asymmetric) synaptic contacts from unlabeled axon terminals. To characterize further the neurotransmitter present in these afferent terminals, we examined in the present study the ultrastructural localization of an antipeptide sequence unique to the mu OR in sections that were also dually labeled for the opioid peptide leucine-enkephalin (L-ENK). Immunogold-silver labeling for mu OR was localized to extrasynaptic portions of the plasma membranes of perikarya and dendrites. The mu OR-labeled dendrites were usually postsynaptic to axon terminals containing heterogeneous types of synaptic vesicles and forming asymmetric synaptic specializations characteristic of excitatory-type synapses. The majority of these were immunolabeled for the endogenous opioid peptide L-ENK. Some mu OR-labeled dendrites received synaptic contacts from unlabeled axon terminals in fields containing L-ENK immunoreactivity. In such cases, the mu OR-labeled dendrites were in proximity to L-ENK axon terminals that ...Continue Reading

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Citations

Mar 3, 2007·Pharmacological Reviews·Jakub FichnaJean-Claude Do Rego
Aug 20, 2002·Japanese Journal of Pharmacology·Qing-Ping WangSeiji Shioda
Nov 1, 1996·Neurochemical Research·A MoriwakiG R Uhl
Nov 9, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Herminio M GuajardoRita J Valentino
Feb 16, 2019·Brain Structure & Function·Beverly A S ReyesElisabeth J Van Bockstaele
Apr 25, 2006·The European Journal of Neuroscience·Beverly A S ReyesElisabeth J Van Bockstaele
Nov 15, 2008·The Journal of Comparative Neurology·B A S ReyesE J van Bockstaele
Dec 12, 2001·Neuroscience·E J Van Bockstaele, K G Commons
Oct 5, 2010·Journal of Chemical Neuroanatomy·B A S ReyesE J Van Bockstaele

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