Abstract
We have previously demonstrated that continuous cocaine treatment for three days induces a marked but transient increase in mu opioid receptor (MOR) mRNA in nucleus accumbens (n. acc.); SCH 23390 and eticlopride, selective antagonists of D1- and D2-like dopamine (DA) receptors, respectively, blocked this cocaine-induced upregulation of MOR mRNA in n. acc. suggesting involvement of both subfamilies of DA receptors in the effect of cocaine (1,2). In the present study the ability of the selective DA D3 receptor antagonist, nafadotride (3,4), to prevent the cocaine-induced upregulation of MOR mRNA in n. acc. has been examined. Also, regulation of MOR mRNA following chronic administration of the DA agonists, SKF 38393, R(+)-6-Bromo-APB hydrobromide, or bromocriptine, has been studied. Male Sprague-Dawley rats were treated for 3 days with saline, cocaine, the DA receptor agonists or antagonist delivered by osmotic minipump. Expression of MOR mRNA in n. acc. was estimated by quantitative competitive polymerase chain reaction (PCR) assays following reverse transcription. Nafadotride (1.0 mg/kg/day) prevented the cocaine-induced upregulation of MOR mRNA in n. acc. When administered alone, nafadotride did not change the expression of MOR...Continue Reading
References
Jun 12, 1992·Brain Research·D W Self, L Stein
Mar 1, 1992·Brain Research. Molecular Brain Research·Y L HurdC R Gerfen
Oct 8, 1992·Nature·P D Siebert, J W Larrick
Oct 1, 1992·Neuroscience·D S Zahm, J S Brog
May 1, 1992·Trends in Pharmacological Sciences·G F Koob
Aug 1, 1991·Pharmacology, Biochemistry, and Behavior·D R BrittonD Kerkman
Jul 1, 1991·Trends in Neurosciences·M J KuharJ W Boja
Nov 15, 1991·Brain Research·M L BouthenetJ C Schwartz
Jan 29, 1990·Brain Research·C B Hubner, G F Koob
Jan 1, 1989·Synapse·R P Hammer
Sep 4, 1987·Science·M C RitzM J Kuhar
Jan 1, 1988·Life Sciences·Y IshizukaI K Ho
Aug 1, 1995·Trends in Pharmacological Sciences·P Sokoloff, J C Schwartz
Apr 1, 1995·Neuroscience·J DiazP Sokoloff
May 1, 1995·Journal of Chemical Neuroanatomy·A MansourS J Watson
Sep 1, 1993·Brain Research. Molecular Brain Research·R SpanglerM J Kreek
Aug 15, 1994·Neuroreport·E M UnterwaldM J Kreek
Sep 1, 1994·Psychopharmacology·S Rosenzweig-LipsonJ Bergman
Jul 1, 1994·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J H Meador-WoodruffS J Watson
Apr 18, 1994·Brain Research·A MansourS J Watson
Feb 1, 1993·The European Journal of Neuroscience·B LandwehrmeyerJ M Palacios
May 1, 1993·Pharmacology, Biochemistry, and Behavior·R MaldonadoG F Koob
Aug 15, 1995·Biological Psychiatry·J H Meador-WoodruffS J Watson
Oct 9, 1995·The Journal of Comparative Neurology·E J Curran, S J Watson
Feb 1, 1996·Journal of Neurochemistry·A V AzaryanB M Cox
Apr 1, 1996·Journal of Neurochemistry·M E ShetreatS Rayport
Dec 15, 1995·Neuroreport·R A LahtiC A Tamminga
Aug 1, 1996·Brain Research. Molecular Brain Research·P RomualdiS Ferri
Feb 1, 1996·Psychopharmacology·D W SelfL Stein
Jan 1, 1997·Neuroscience·B Búzás, B M Cox
Citations
Sep 3, 2008·Psychopharmacology·David A GorelickJ James Frost
Nov 10, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Cheol Kyu HwangHorace H Loh
Jun 14, 2005·Brain Research. Molecular Brain Research·Alexis BaileyMary Jeanne Kreek
Feb 5, 1998·European Journal of Pharmacology·F SehbaB C Yoburn
Jun 3, 1999·Brain Research. Molecular Brain Research·A VecchiolaK Magendzo
Jun 5, 2002·Neuroscience·C Le MoineM Jaber
Aug 26, 1998·Drug and Alcohol Dependence·M J Kreek, G F Koob
Nov 18, 1998·Alcohol·W J McBrideT K Li
Aug 24, 1999·Alcohol·N T Jamensky, C Gianoulakis
Jun 22, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Thomas J MartinJames E Smith
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·P Y LawH H Loh
Oct 20, 2012·BMC Pharmacology & Toxicology·Warren Winick-NgBettina E Kalisch
Apr 21, 1999·Brain Research Bulletin·V YuferovM J Kreek
May 1, 2009·Expert Opinion on Drug Discovery·Erin Cummins, Francesco Leri
Jul 8, 2008·Progress in Neurobiology·Ilana Roth-DeriGal Yadid
Aug 12, 2015·NeuroImage·Lauri TuominenLauri Nummenmaa
Apr 4, 2016·Neuroscience·Janaine C CarvalhoEgberto G Moura
Jun 15, 2005·Biological Psychiatry·David A GorelickJ James Frost
Apr 29, 2014·Behavioural Brain Research·Emilio Domínguez-SalazarJavier Velázquez-Moctezuma
Sep 23, 2014·Pain·Zigor AiraJon Jatsu Azkue
Oct 9, 1998·The Journal of Biological Chemistry·J L KoH H Loh
Jun 17, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Almudena López-FandoJavier Garzón
Jun 16, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·James E SmithThomas J Martin
Mar 21, 2012·British Journal of Pharmacology·Ji Hoon YooAlexis Bailey
Oct 2, 2019·Journal of Dual Diagnosis·Hye Bin YooFrancesca M Filbey
Jul 13, 2000·Synapse·L G SharpeE D London
Jul 19, 2001·Annals of the New York Academy of Sciences·E M Unterwald
May 17, 2001·Molecular Pharmacology·H J ImH H Loh
Jul 12, 2018·Psychopharmacology·Rachel-Karson ThériaultBettina Kalisch
May 1, 2021·International Journal of Molecular Sciences·Anna de Corde-SkurskaMagdalena Bujalska-Zadrozny