PMID: 8947931Nov 1, 1996Paper

Mu opioid receptor mRNA in nucleus accumbens is elevated following dopamine receptor activation

Neurochemical Research
A V AzaryanB M Cox

Abstract

We have previously demonstrated that continuous cocaine treatment for three days induces a marked but transient increase in mu opioid receptor (MOR) mRNA in nucleus accumbens (n. acc.); SCH 23390 and eticlopride, selective antagonists of D1- and D2-like dopamine (DA) receptors, respectively, blocked this cocaine-induced upregulation of MOR mRNA in n. acc. suggesting involvement of both subfamilies of DA receptors in the effect of cocaine (1,2). In the present study the ability of the selective DA D3 receptor antagonist, nafadotride (3,4), to prevent the cocaine-induced upregulation of MOR mRNA in n. acc. has been examined. Also, regulation of MOR mRNA following chronic administration of the DA agonists, SKF 38393, R(+)-6-Bromo-APB hydrobromide, or bromocriptine, has been studied. Male Sprague-Dawley rats were treated for 3 days with saline, cocaine, the DA receptor agonists or antagonist delivered by osmotic minipump. Expression of MOR mRNA in n. acc. was estimated by quantitative competitive polymerase chain reaction (PCR) assays following reverse transcription. Nafadotride (1.0 mg/kg/day) prevented the cocaine-induced upregulation of MOR mRNA in n. acc. When administered alone, nafadotride did not change the expression of MOR...Continue Reading

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Citations

Nov 10, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Cheol Kyu HwangHorace H Loh
Jun 14, 2005·Brain Research. Molecular Brain Research·Alexis BaileyMary Jeanne Kreek
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Oct 20, 2012·BMC Pharmacology & Toxicology·Warren Winick-NgBettina E Kalisch
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Aug 12, 2015·NeuroImage·Lauri TuominenLauri Nummenmaa
Apr 29, 2014·Behavioural Brain Research·Emilio Domínguez-SalazarJavier Velázquez-Moctezuma
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Jun 16, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·James E SmithThomas J Martin
Oct 2, 2019·Journal of Dual Diagnosis·Hye Bin YooFrancesca M Filbey
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May 1, 2021·International Journal of Molecular Sciences·Anna de Corde-SkurskaMagdalena Bujalska-Zadrozny

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