MUC1 enhances tumor progression and contributes toward immunosuppression in a mouse model of spontaneous pancreatic adenocarcinoma.

The Journal of Immunology : Official Journal of the American Association of Immunologists
T L TinderPinku Mukherjee

Abstract

MUC1, a membrane tethered mucin glycoprotein, is overexpressed and aberrantly glycosylated in >80% of human ductal pancreatic adenocarcinoma. However, the role of MUC1 in pancreatic cancer has been elusive, partly due to the lack of an appropriate model. We report the characterization of a novel mouse model that expresses human MUC1 as a self molecule (PDA.MUC1 mice). Pancreatic tumors arise in an appropriate MUC1-tolerant background within an immune-competent host. Significant enhancement in the development of pancreatic intraepithelial preneoplastic lesions and progression to adenocarcinoma is observed in PDA.MUC1 mice, possibly due to increased proliferation. Tumors from PDA.MUC1 mice express higher levels of cyclooxygenase-2 and IDO compared with PDA mice lacking MUC1, especially during early stages of tumor development. The increased proinflammatory milieu correlates with an increased percentage of regulatory T cells and myeloid suppressor cells in the pancreatic tumor and tumor draining lymph nodes. Data shows that during pancreatic cancer progression, MUC1-mediated mechanisms enhance the onset and progression of the disease, which in turn regulate the immune responses. Thus, the mouse model is ideally suited for testing ...Continue Reading

References

Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D L BarndO J Finn
Dec 15, 1995·The Journal of Biological Chemistry·A P SpicerS J Gendler
Jul 27, 1999·International Journal of Cancer. Journal International Du Cancer·A K ChanP S Goedegebuure
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·P MukherjeeS J Gendler
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E M HiltboldO J Finn
Sep 8, 2001·Journal of Mammary Gland Biology and Neoplasia·S J Gendler
Aug 20, 2002·Nature Genetics·Yoshiya KawaguchiChristopher V E Wright
Sep 7, 2002·The Journal of Biological Chemistry·Kiyoshi TakayamaPeter Libby
Nov 28, 2002·International Journal of Cancer. Journal International Du Cancer·Yuichiro HamanakaYuji Hinoda
Jan 7, 2003·Journal of Immunotherapy·Pinku MukherjeeSandra J Gendler
Feb 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Takaaki InabaHiroshi Nakada
Sep 19, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anirban MaitraRalph H Hruban
Dec 18, 2003·Journal of Experimental Therapeutics & Oncology·Seiichiro KaiSeigo Kitano
Jan 7, 2004·Cancer Cell·Sunil R HingoraniDavid A Tuveson
Jan 10, 2004·Journal of Gastroenterology·Yuji HinodaSuguru Yonezawa
Jan 15, 2004·Trends in Molecular Medicine·David H Munn, Andrew L Mellor
Mar 19, 2004·The New England Journal of Medicine·John P NeoptolemosUNKNOWN European Study Group for Pancreatic Cancer
Apr 29, 2004·Journal of Clinical Pathology·E LeviN V Adsay
May 22, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hind NassarVolkan Adsay
Jun 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paolo MontiLorenzo Piemonti
Oct 2, 2004·Nature Reviews. Immunology·Andrew L Mellor, David H Munn
Oct 12, 2004·Journal of Proteome Research·Mads GrønborgAkhilesh Pandey
Oct 21, 2004·British Journal of Cancer·N MoniauxS K Batra
Oct 30, 2004·Journal of Leukocyte Biology·P MukherjeeS J Gendler
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aurelia RughettiMarianna Nuti
Jul 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Casey A CarlosOlivera J Finn
Nov 4, 2005·Cancer Research·Friedrich H Schmitz-WinnenthalPhilipp Beckhove
Dec 14, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David V GoldDavid M Goldenberg
Feb 10, 2006·Journal of Clinical Pathology·A JuutiC Haglund
Mar 4, 2006·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Jul 19, 2006·Breast Cancer Research : BCR·Christine L Hattrup, Sandra J Gendler
Jul 25, 2006·Nature Reviews. Cancer·Alexander J Muller, Peggy A Scherle
Aug 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gargi D BasuPinku Mukherjee
Dec 13, 2006·Breast Cancer Research : BCR·Gargi D BasuPinku Mukherjee
Mar 17, 2007·Clinical and Experimental Immunology·M I TorresA Ríos

❮ Previous
Next ❯

Citations

May 1, 2012·Cancer Immunology, Immunotherapy : CII·Jorge SchettiniPinku Mukherjee
Sep 20, 2011·The International Journal of Biological Markers·Angel González-SistalAlvaro Ruibal
Nov 2, 2012·Cancer Metastasis Reviews·Wanglong Qiu, Gloria H Su
Nov 29, 2012·The Cancer Journal·Christoph Benedikt Westphalen, Kenneth P Olive
Apr 11, 2013·Cancer Investigation·Krishna PillaiDavid Lawson Morris
Jul 17, 2013·Nature Reviews. Gastroenterology & Hepatology·Sukhwinder KaurSurinder K Batra
Sep 26, 2013·Immunopharmacology and Immunotoxicology·Caroline B MadsenAnders Elm Pedersen
Jun 3, 2015·Pancreas·Sritama NathPinku Mukherjee
Sep 6, 2019·Journal of Cancer Research and Clinical Oncology·Bastian CzogallaAnna Hester
Dec 22, 2019·Genes·Marina Ayres Pereira, Iok In Christine Chio
Feb 17, 2009·Expert Opinion on Biological Therapy·Michael A MorseJanet M D Plate
Dec 7, 2016·Oncology Reports·Caterina MusolinoSebastiano Gangemi
Jun 19, 2009·Expert Opinion on Therapeutic Targets·P H Tan, A K Bharath
Jan 6, 2010·Zebrafish·Jennifer M BaileyMichael A Hollingsworth
Jan 1, 2010·Cancers·Nicolas JonckheereIsabelle Van Seuningen
Jul 20, 2010·Immunotherapy·Richard E BeatsonJoy M Burchell
Apr 7, 2017·International Journal of Molecular Sciences·Mohammad Aslam Aslam KhanAjay Pratap Singh
Aug 4, 2020·Journal of Cellular and Molecular Medicine·Shunda WangYupei Zhao
Mar 18, 2016·International Journal of Oncology·Enrique P GarcíaTeresa Freire
Mar 22, 2016·International Journal of Cancer. Journal International Du Cancer·Ping WangAnna Moore
Jul 7, 2017·Genes & Cancer·Lopamudra Das RoyPinku Mukherjee
Jan 31, 2015·Cancer Metastasis Reviews·Suhasini JoshiSurinder K Batra
Nov 19, 2015·BioMed Research International·Chen ChenXiao Ming Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.