MUC1 gene-derived glycoprotein assays for monitoring breast cancer (CA 15-3, CA 27.29, BR): are they measuring the same antigen?

Archives of Pathology & Laboratory Medicine
George G Klee, William E Schreiber

Abstract

There are 2 general types of assays measuring MUC1 gene-derived glycoprotein: assays for cancer antigen (CA) 15-3, which are sandwich assays, and assays for CA 27.29, which are competitive assays. These 2 types of assays measure slightly different parts of this tandem-repeat molecule. Across-method assay differences hinder the exchange of patient test values among integrated health care networks and among countries. This report evaluates the method differences among these assays to determine if the differences between these assays are mainly related to variations in calibration or differences in analyte specificity. Data from 22 College of American Pathologists survey challenges were analyzed to compare 10 commercial assay methods for these 2 related analytes. In addition, data from 58 patient samples were analyzed to compare 3 of these assays. The linear correlation coefficients comparing the within-method medians of these proficiency test distributions were very high (>0.99) for all of the methods; however, the regression slopes varied from 0.836 to 1.095. The regression slopes for the patient specimens varied similarly, but the correlation coefficients were lower. This study indicates that many of the test value differences ...Continue Reading

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Citations

Feb 13, 2013·Molecular & Cellular Proteomics : MCP·Kevin Chandler, Radoslav Goldman
May 2, 2009·Biochimica Et Biophysica Acta·Michael A Tainsky
Mar 22, 2007·Expert Opinion on Biological Therapy·Ravi A MadanJames L Gulley
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Sep 8, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Michael J DuffyEnda W McDermott

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Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

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