MUC1 regulates AKT signaling pathway by upregulating EGFR expression in ovarian cancer cells.

Pathology, Research and Practice
Qingxia MaNingning He

Abstract

MUC1, a type I transmembrane glycoprotein, mediates tumor growth and cellular differentiation in various types of cancers. However, the mechanism of MUCI in ovarian cancer has not been fully clarified. In our study, we have observed that MUC1 can play a crucial role in the development and progression of ovarian cancer and act as a predictive marker. We also found that MUC1 could increase the expression of EGFR, and MUC1-EGFR co-administration could promote the cellular growth via the AKT pathway. Taxol is an important drug for treating ovarian cancer, which can prevent cancer recurrence and reduce mortality. Our data have collectively reflected that Taxol can prevent ovarian cancer with abnormal expression of MUC1.

References

Mar 17, 2001·Nature Reviews. Molecular Cell Biology·Y Yarden, M X Sliwkowski
Dec 19, 2003·Nature Reviews. Cancer·Michael A Hollingsworth, Benjamin J Swanson
Apr 8, 2004·Neoplasia : an International Journal for Oncology Research·Daniel R RhodesArul M Chinnaiyan
Dec 14, 2004·The New England Journal of Medicine·Stephen A Cannistra
Sep 24, 2011·Nature Reviews. Cancer·Sebastian VaughanFrances R Balkwill
Jan 11, 2013·Cell Adhesion & Migration·Teresa M Horm, Joyce A Schroeder
May 21, 2013·Journal of Cellular Biochemistry· Neeraja DharmarajDaniel D Carson
Mar 29, 2014·Trends in Molecular Medicine·Sritama Nath, Pinku Mukherjee
Sep 6, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Akriti KharbandaDonald Kufe
Mar 4, 2015·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Mrunal V KesariAmeya V Khadilkar
Mar 26, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xiaofang SunDaolin Tang
Apr 20, 2016·Oncotarget·Brian J EngelDaniel D Carson
Nov 3, 2016·Breast Cancer Research and Treatment·András LánczkyBalázs Győrffy
Aug 18, 2017·Anti-cancer Drugs·Patrick M ReevesMark C Poznansky
Dec 22, 2017·Cancer Research·Takahiro MaedaDonald Kufe
Feb 17, 2018·EMBO Molecular Medicine·Azhar AliDaniel G Tenen
May 29, 2018·CA: a Cancer Journal for Clinicians·Lindsey A TorreRebecca L Siegel
Mar 29, 2019·Journal of Ovarian Research·Vincent DochezGuillaume Ducarme
Jul 6, 2019·Cancer Research·Jeffrey H BeckerTakeshi Shimamura
Jul 18, 2019·Molecular Carcinogenesis·Hao ZhengWei-Ping Zhou
Oct 4, 2020·Molecular Biology Reports·Haotian LuLing Li

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