MUC2 expression in human middle ear epithelium of patients with otitis media.

Archives of Otolaryngology--head & Neck Surgery
Matthew L UbellAmy Burrows

Abstract

To compare levels of expression of mucin gene 2 (MUC2), a major secretory mucin, in the middle ear of patients with otitis media (OM) and control patients. Case-control study. Children's Hospital of Wisconsin, Milwaukee. Nineteen patients aged 6 months to 15 years undergoing routine ventilation tube insertion for recurrent OM or chronic OM with effusion and 8 controls with no history of OM undergoing cochlear implantation. Biopsy of middle ear epithelium for RNA extraction. Expression of MUC2 by real-time reverse transcription-polymerase chain reaction. Twenty-seven OM samples (17 recurrent and 10 with effusion) from 19 patients were analyzed and compared with 9 control samples from 8 patients. The mean MUC2 expression was 6.12 (95% confidence interval, 3.32-8.89) times that of the controls in the OM samples overall, 5.00 (95% confidence interval, 2.79-7.21) times that of controls in the recurrent OM samples, and 7.98 (95% confidence interval, 1.58-14.38) times that of controls in the OM with effusion samples. Levels of MUC2 expression in human middle ear epithelium are significantly increased in patients with OM overall, patients with recurrent OM, and patients with OM with effusion compared with controls. Mucins are fundament...Continue Reading

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Citations

Jun 25, 2014·International Journal of Pediatric Otorhinolaryngology·Joseph E KerschnerNikki Johnston
Dec 2, 2014·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Rahul MittalXue-Zhong Liu
Aug 18, 2010·Archives of Otolaryngology--head & Neck Surgery·Joseph E KerschnerBlake C Papsin
Sep 18, 2010·International Journal of Pediatric Otorhinolaryngology·Joseph E KerschnerP Khampang
Apr 21, 2009·Cellular Microbiology·Luanne Hall-Stoodley, Paul Stoodley
Sep 1, 2009·The Laryngoscope·Matthew L UbellJoseph E Kerschner
Dec 3, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Rahul MittalXue Zhong Liu
Apr 3, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Per Cayé-ThomasenJorge Spratley
Apr 3, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Howard J HoffmanLouis Vernacchio
Apr 3, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jian-Dong LiJ Christopher Post
Jun 10, 2010·Pediatric Research·Diego PreciadoMary C Rose

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