MUC5AC and MUC5B enhance the characterization of mucinous adenocarcinomas of the lung and predict poor prognosis

Histopathology
Young K KimMi H Kim

Abstract

From the viewpoint of histogenesis, lung adenocarcinoma can be subdivided into two groups: terminal respiratory unit (TRU) and non-TRU types. We recently reported a non-TRU type adenocarcinoma designated as ciliated adenocarcinoma (we now prefer central type adenocarcinoma). We suggest reasons that mucinous adenocarcinoma should encompass central type adenocarcinoma to represent its biological characteristics as non-TRU type adenocarcinoma. Mucin (MUC)5AC and MUC5B were expressed more significantly in non-TRU type adenocarcinoma (P < 0.01). Thirty-five (76.1%) and 45 cases (97.8%) of 46 non-TRU type adenocarcinoma showed positivity for MUC5AC and MUC5B. Twelve (7.6%) and eight (5.1%) cases of 157 TRU type adenocarainoma showed positivity for MUC5B and MUC5AC. NKX2-1 gene expression was measured with quantitative reverse transcription-polymerase chain reaction (qRT-PCR). ΔΔCt of NKX2-1 gene expression was 6.79 for TRU type adenocarcinoma and 0.6 for non-TRU type adenocarcinoma. Overall survival and disease-free survival were poorer in non-TRU type adenocarcinoma (P = 0.02 and P = 0.03). A multivariate test also showed that non-TRU type adenocarcinoma is an independent prognostic factor (P = 0.04). MUC5AC and MUC5B were specific ...Continue Reading

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Citations

Jan 18, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Luisella RighiMauro Papotti
Feb 23, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·X H GuoN Zhao
Jun 24, 2017·Journal of Cellular Biochemistry·Wei WangXiang-Yu Sun
Dec 21, 2019·Pathology International·Ryo WakejimaYuichi Ishikawa
Oct 16, 2019·International Journal of Surgical Pathology·Deniz TuncelVolkan Adsay
Nov 18, 2018·International Journal of Molecular Sciences·Akira SaitoTakahide Nagase
Aug 10, 2018·JCI Insight·Alison K BauerSeyed Javad Moghaddam
Aug 14, 2019·Chest·Stacey-Ann Whittaker BrownJuan Wisnivesky
Sep 28, 2021·Interactive Cardiovascular and Thoracic Surgery·Dae Hyeon KimYoung Tae Kim

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