Mucin-1-Antibody-Conjugated Mesoporous Silica Nanoparticles for Selective Breast Cancer Detection in a Mucin-1 Transgenic Murine Mouse Model

Journal of Biomedical Nanotechnology
Didier DréauJuan L Vivero-Escoto

Abstract

Mucin-1 (MUC1), a transmembrane glycoprotein is aberrantly expressed on ~90% of breast cancer and is an excellent target for nanoparticulate targeted imaging. In this study, the development of a dye-doped NIR emitting mesoporous silica nanoparticles platform conjugated to tumor-specific MUC1 antibody (ab-tMUC1-NIR-MSN) for in vivo optical detection of breast adenocarcinoma tissue is reported. The structural properties, the in vitro and in vivo performance of this nanoparticle-based probe were evaluated. In vitro studies showed that the MSN-based optical imaging nanoprobe is non-cytotoxic and targets efficiently mammary cancer cells overexpressing human tMUC1 protein. In vivo experiments with female C57BL/6 mice indicated that this platform accumulates mainly in the liver and did not induce short-term toxicity. In addition, we demonstrated that the ab-tMUC1-NIR-MSN nanoprobe specifically detects mammary gland tumors overexpressing human tMUC1 in a human MUC1 transgenic mouse model.

Citations

Mar 23, 2019·Expert Opinion on Drug Delivery·Rafael R CastilloMaría Vallet-Regí
Nov 9, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Juan L Vivero-EscotoJennifer H Benbow
Jul 7, 2017·Genes & Cancer·Lopamudra Das RoyPinku Mukherjee
Jul 2, 2020·International Journal of Nanomedicine·Yan WangQi Li
Jul 2, 2019·Advanced Functional Materials·Lauren RackleyKirill A Afonin
Aug 25, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Rachael M CristStephan T Stern
Aug 23, 2020·International Journal of Molecular Sciences·Alberto JuanCarlos Alonso-Moreno
May 14, 2020·Nanomaterials·Miguel Gisbert-Garzarán, María Vallet-Regí
Apr 24, 2021·Expert Opinion on Drug Delivery·Seyed Mehdi Kamali ShahriMorteza Mahmoudi
Jul 6, 2021·International Journal of Biological Macromolecules·Jamileh KadkhodaAyuob Aghanejad
Jul 23, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kristina ŽivojevićNikola Ž Knežević
Jun 28, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Mathieu VaracheFrédéric Bouyer
Aug 19, 2020·ACS Applied Materials & Interfaces·Ridhima JunejaJuan L Vivero-Escoto

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