Mucin as a therapeutic target in pseudomyxoma peritonei

Journal of Surgical Oncology
Haroon A ChoudryDavid L Bartlett

Abstract

Pseudomyxoma peritonei (PMP) is characterized by intraperitoneal dissemination of mucinous ascites. This malignancy frequently recurs despite aggressive locoregional therapies, demonstrates chemo-insensitivity and lacks targeted therapies. This review addresses some intriguing questions in PMP; what role does mucin play in this malignancy?; what genetic alterations and dysregulated signaling pathways lead to a putative goblet cell-lineage differentiation or mucin overexpression?; are targeted therapies against known transcriptional pathways for mucin production a novel therapeutic strategy in this malignancy?

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Citations

Jul 13, 2013·Orphanet Journal of Rare Diseases·Jeremy J GilbreathD Scott Merrell
Jun 3, 2014·Orphanet Journal of Rare Diseases·Afshin AminiDavid Lawson Morris
Nov 22, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Ashok K DillyHaroon A Choudry
Apr 19, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Ashok K DillyHaroon A Choudry
Jun 13, 2019·Annals of Surgical Oncology·Marian KhaliliWilbur B Bowne
May 30, 2013·American Society of Clinical Oncology Educational Book·Rebecca Buell-Gutbrod, Katja Gwin
Aug 20, 2020·Orphanet Journal of Rare Diseases·Ashok K DillyHaroon A Choudry
May 3, 2018·Annals of Surgical Oncology·Haroon A Choudry, Reetesh K Pai
Nov 10, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Ashok K DillyHaroon A Choudry

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