Mucin genes have different expression patterns in healthy and diseased upper airway mucosa

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
A Martínez-AntónJ Mullol

Abstract

Mucus hyper-secretion is a feature of several airways diseases such as chronic rhinosinusitis, asthma, and cystic fibrosis (CF). Since mucins are major components of mucus, the knowledge of their distribution and regulation in nasal tissues is likely to improve mucus hyper-secretion therapy. The aim of this study was to evaluate and compare mucin gene expression at epithelial and glandular levels, and to identify potential mucin expression patterns for specific upper airways pathologies. Immunohistochemistry for MUC1, MUC2, and MUC4-MUC8 mucins was performed on healthy nasal mucosa (NM; n=12), bilateral nasal polyps (NP; n=38), NP from CF patients (n=10), and antrochoanal (AC) polyps (n=11). MUC2, MUC4, MUC5AC, and MUC6 mRNA expression were also analysed by in situ hybridization. MUC1, MUC4, and MUC5AC mucins were highly expressed in the epithelium and their expression pattern was similar in all NP types, MUC1 and MUC4 being increased and MUC5AC decreased compared with NM. MUC8 was highly detected at both epithelial and glandular levels with marked variability between groups. MUC5B was mainly detected in glands and the expression in all polyp types was higher than in NM. Moreover, MUC5B expression was higher in NP epithelia fro...Continue Reading

References

Nov 15, 1985·International Journal of Cancer. Journal International Du Cancer·M R PriceR W Baldwin
Feb 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·J D LiC B Basbaum
Apr 1, 1997·Clinical Otolaryngology and Allied Sciences·J M Rowe-JonesI S Mackay
Jul 1, 1997·American Journal of Rhinology·M R AustS J Gendler
Jun 19, 1998·Biochimica Et Biophysica Acta·A DohrmanC Basbaum
Jul 3, 1998·International Journal of Cancer. Journal International Du Cancer·C de BolòsF X Real
Feb 20, 1999·The Journal of Biological Chemistry·K L CarrawayK L Carraway
Jul 10, 1999·The Journal of Allergy and Clinical Immunology·C LamblinB Wallaert
Jun 6, 2000·American Journal of Respiratory Cell and Molecular Biology·J LouahedN C Nicolaides
Oct 14, 2000·The Journal of Allergy and Clinical Immunology·P R BurgelJ A Nadel
Nov 4, 2000·American Journal of Respiratory Cell and Molecular Biology·L E VinallD M Swallow
Dec 29, 2000·The Laryngoscope·C H KimJ H Yoon
Jan 12, 2001·American Journal of Respiratory Cell and Molecular Biology·A López-Ferrer de Bolós C
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·C L OrdoñezJ V Fahy
Oct 17, 2001·The Journal of Biological Chemistry·C Wickström, I Carlstedt
Nov 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·P R BurgelJ A Nadel
Nov 20, 2001·American Journal of Respiratory Cell and Molecular Biology·M C RoseJ A Voynow
Feb 22, 2002·Biochemical and Biophysical Research Communications·James R GumYoung S Kim
Apr 12, 2002·Histopathology·D A GronebergK F Chung
Jun 6, 2002·European Journal of Biochemistry·Lone T PallesenJan T Rasmussen
Mar 5, 2003·The Laryngoscope·David A GronebergK Fan Chung
Feb 28, 2004·American Journal of Respiratory Cell and Molecular Biology·Markus O HenkeBruce K Rubin
Jun 24, 2004·Archives of Otolaryngology--head & Neck Surgery·Dae Hoon KimHeung-Man Lee
Aug 28, 2004·The Annals of Otology, Rhinology, and Laryngology·Heung-Man LeeSoon Jae Hwang
Oct 2, 2004·The European Respiratory Journal·P-R BurgelJ A Nadel

❮ Previous
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Citations

Apr 4, 2006·Current Allergy and Asthma Reports·Asunción Martínez-AntónJoaquim Mullol
Feb 5, 2009·DNA and Cell Biology·Eun-Kyung AhnSun-Hee Leem
Sep 14, 2007·Annual Review of Physiology·Christine L Hattrup, Sandra J Gendler
Jul 5, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Walter E FinkbeinerJonathan H Widdicombe
Jan 27, 2007·American Journal of Respiratory and Critical Care Medicine·Markus O HenkeBruce K Rubin
Jul 20, 2010·American Journal of Respiratory Cell and Molecular Biology·Sang-Nam LeeJoo-Heon Yoon
Mar 6, 2015·Biological & Pharmaceutical Bulletin·Sveinbjörn Gizurarson
May 26, 2007·The Journal of Physiology·Robert J LeeJ Kevin Foskett
Feb 15, 2009·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Russell H Easy, Neil W Ross
Sep 25, 2007·The Laryngoscope·Chang Hoon BaiYong-Dae Kim
Mar 17, 2007·Allergy·J MullolI Alobid
Jun 22, 2010·Journal of Cellular Biochemistry·Uk Yeol MoonJoo-Heon Yoon
Apr 8, 2014·Cell Calcium·Robert J Lee, J Kevin Foskett
May 13, 2009·Clinical and Experimental Otorhinolaryngology·De Yun Wang
Nov 29, 2014·Current Allergy and Asthma Reports·De-Yun WangLi Shi
May 11, 2010·Journal of Pharmacological Sciences·Yuki NishimotoYoichiro Isohama
Jul 10, 2016·The Journal of Allergy and Clinical Immunology. in Practice·Seong Ho ChoPhilippe Gevaert
Aug 10, 2016·Allergology International : Official Journal of the Japanese Society of Allergology·Yasuyuki NoyamaKazunori Nishizaki
Sep 19, 2016·The Journal of Allergy and Clinical Immunology·Javier MilaraJulio Cortijo
Sep 27, 2008·Archives of Oral Biology·Denise G SilvaEduardo M B Tinoco
Sep 24, 2016·American Journal of Rhinology & Allergy·Benjamin M Hariri, Noam A Cohen
Apr 11, 2014·American Journal of Rhinology & Allergy·Dimitrios BatzakakisStephanos Naxakis
Aug 16, 2008·American Journal of Rhinology·Annarita PalombaAlessandro Franchi
Mar 4, 2014·Allergy, Asthma & Immunology Research·Seung-Heon ShinJeong-Kyu Kim
Jun 18, 2009·Current Opinion in Allergy and Clinical Immunology·Mahmoud El-Sayed Ali
Dec 8, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Robert J Lee, J Kevin Foskett
Jul 14, 2019·Chemical Senses·Christopher KennelVijay R Ramakrishnan
Sep 4, 2015·Physiological Reviews·Jonathan H Widdicombe, Jeffrey J Wine
Sep 14, 2019·Journal of Clinical Medicine·Beatriz BallesterJulio Cortijo
Nov 21, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Sophie GohyCharles Pilette
May 13, 2020·Ear, Nose, & Throat Journal·Muhammed YaylaMustafa SitkiGozeler
Jul 24, 2020·Facial Plastic Surgery & Aesthetic Medicine·Ludovic de GaboryLaurence Bordenave
Jan 26, 2017·Tuberculosis and Respiratory Diseases·Orapan PoachanukoonNapaporn Pattanacharoenchai
Mar 21, 2019·American Journal of Rhinology & Allergy·Kosuke KatoEugene H Chang

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