PMID: 2496524Jan 1, 1989Paper

Mucin immunohistochemistry of the columnar epithelium of the oesophagus (Barrett's oesophagus)

Virchows Archiv. A, Pathological Anatomy and Histopathology
V DuchatelleD Goldfain

Abstract

Columnar cell lined lower oesophagus (CELLO), often considered to be a precancerous lesion, is characterized by a glandular mucosa with a predominance of sulphomucins in the specialized epithelium. This histochemical abnormality can be correlated with abnormal differentiation which may also be studied by anti-mucus antibodies (anti-M1, anti-M3, anti-SIMA, anti-LIMA). The purpose of this prospective study is to define the mucin profile in a large population of CELLO by immunohistochemistry and to compare it with the results of histochemistry. Biopsies of 79 patients with reflux oesophagitis were included. Thirty-eight had CELLO and 41 had a histologically normal cardia. Six surgical specimens of oesophageal adenocarcinomas were also included. The histochemical methods confirmed the preponderance (57.9%) of type III intestinal metaplasia (IM) found in 57.9% of cases. The immunohistochemical methods showed a similar antigenic profile of type II and III IM with positivity of anti-SIMA and anti-M3 antibodies in the goblet cells, and positivity of anti-LIMA antibodies in both the goblet and intermediate cells of the specialized epithelium. The mucus secreting cells of the oesophageal adenocarcinomas had the same immunohistochemical p...Continue Reading

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Citations

Jun 18, 2002·Journal of Cellular and Molecular Medicine·J R Jass, M D Walsh
Mar 11, 2009·World Journal of Surgical Oncology·Sergio SzachnowiczAdriana Vaz Safatle-Ribeiro
Nov 5, 2014·Nature Reviews. Gastroenterology & Hepatology·Stuart A C McDonaldMarnix Jansen
Jul 30, 2008·Surgical and Radiologic Anatomy : SRA·A SteccoR De Caro
May 15, 2001·The British Journal of Surgery·M L ThomasG J Maddern

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