Mucin-like carcinoma-associated antigen (MCA) during normal pregnancy

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Angeliki SarandakouI Phocas

Abstract

To assess the usefulness of Mucin-like carcinoma-associated antigen (MCA) in monitoring pregnant patients with breast cancer. Maternal serum (MS) and amniotic fluid (AF) antigen values were measured by an enzyme immunoassay in 30 pregnant women during the second trimester, in 28 during the third and in 26 at parturition. Sera only from 26 women in the first trimester and from 26 healthy, non-pregnant women (controls) were also analyzed. Maternal serum MCA concentrations increased significantly with gestational age (p<0.0001). The frequency of elevated serum values was 5% in the first, 35% in the second and 100% in the third trimester and at parturition. Antigen values in AF were markedly higher than those in MS (p<0.0001) and increased also significantly with advancing gestation (p<0.0001). A strong correlation was observed between MS and AF antigen values (r=0.77, p<0.0001). Maternal serum values at parturition were dependent on the mode of delivery, being higher in the cases who delivered vaginally, compared to those delivered by elective caesarean section (p<0.006). Our data suggest that pregnancy affects significantly maternal serum MCA. Consequently, MCA seems to be a non-reliable marker in monitoring pregnant patients.

References

May 13, 1992·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A SarandakouI Phocas
Jan 1, 1991·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·C BieglmayerM Strasser
Jan 1, 1989·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·C BieglmayerC Nowotny
Sep 1, 1983·Journal of Reproductive Immunology·M S Hamilton
Oct 1, 1994·Prenatal Diagnosis·P HohlfeldF Forestier
Apr 29, 1998·American Journal of Reproductive Immunology : AJRI·F Botelho, D A Clark

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Citations

Oct 17, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Galini GiannakiIphigenia Phocas
Mar 17, 2007·Critical Reviews in Clinical Laboratory Sciences·Angeliki SarandakouDemetrios Rizos

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