Mucin-Microbiota Interaction During Postnatal Maturation of the Intestinal Ecosystem: Clinical Implications

Digestive Diseases and Sciences
Sana RokhsefatElena M Comelli

Abstract

The mucus layer and gut microbiota interplay contributes to host homeostasis. The mucus layer serves as a scaffold and a carbon source for gut microorganisms; conversely, gut microorganisms, including mucin degraders, influence mucin gene expression, glycosylation, and secretion. Conjointly they shield the epithelium from luminal pathogens, antigens, and toxins. Importantly, the mucus layer and gut microbiota are established in parallel during early postnatal life. During this period, the development of gut microbiota and mucus layer is coupled with that of the immune system. Developmental changes of different mucin types can impact the age-dependent patterns of intestinal infection in terms of incidence and severity. Altered mucus layer, dysbiotic microbiota, and abnormal mucus-gut microbiota interaction have the potential for inducing systemic effects, and accompany several intestinal diseases such as inflammatory bowel disease, colorectal cancer, and radiation-induced mucositis. Early life provides a pivotal window of opportunity to favorably modulate the mucus-microbiota interaction. The support of a health-compatible mucin-microbiota maturation in early life is paramount for long-term health and serves as an important oppo...Continue Reading

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Citations

Aug 3, 2017·Digestive Diseases and Sciences·Larry L BartonHenry C Lin
Sep 13, 2017·Scientific Reports·Van T PhamChristophe Chassard
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Feb 14, 2021·Physiological Reports·Aline Vasques da CostaPatrícia Gama
Jul 13, 2021·Biotechnology Advances·Elora FournierStéphanie Blanquet-Diot

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