Mucin phenotypic expression and background mucosa of esophagogastric junctional adenocarcinoma

Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Naoko TsujiMasatoshi Kudo

Abstract

In the West, the incidence of adenocarcinoma of the cardia or esophagogastric junction (EGJ) is increasing. This carcinoma is variously defined, however, and it contains heterogeneous tumors. In Japan, the frequency of this carcinoma is low, and little is known about it. We studied small esophagogastric junctional adenocarcinoma to determine its characteristics in Japanese patients. Fifty-four patients with Siewert type II junctional adenocarcinoma (with tumors <4 cm in maximum diameter) were studied. The carcinomas were classified into two types: tumors straddling the EGJ (EGJ-type) and tumors occurring entirely below the EGJ (bEGJ-type). Characteristics of the tumors and surrounding mucosae were evaluated. Phenotypic expression of mucin, p53 overexpression, and Helicobacter pylori infection were investigated histologically and immunohistochemically. Twenty-three (43%) patients had EGJ-type and 31 (57%) had bEGJ-type carcinomas. The ratio of advanced cancers was significantly higher in EGJ-type. Some between-group similarities and differences existed in histological type, mucin phenotype, and p53 protein overexpression, but they were not statistically significant. In the mucosa surrounding EGJ-type tumors vs bEGJ-type tumors, ...Continue Reading

Citations

Dec 19, 2006·International Journal of Surgical Pathology·Qin Huang, Li Hua Zhang
Apr 4, 2009·The American Journal of Gastroenterology·M Vieth, H Barr
Nov 14, 2013·Japanese Journal of Clinical Oncology·Masayoshi YamadaTadakazu Shimoda
Dec 18, 2014·The American Journal of Surgical Pathology·Junko AidaKaiyo Takubo

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