Mucin-poor and aggressive mucinous tubular and spindle cell carcinoma of the kidney: Two case reports

Molecular and Clinical Oncology
Shiro UchidaYoji Nagashima

Abstract

Mucinous tubular and spindle cell carcinoma (MTSCC) is a relatively rare renal epithelial neoplasm. Although MTSCC is considered to be a low-grade and indolent neoplasm, aggressive cases have been recently reported. The present study discussed two additional cases of high-grade MTSCC causing multiple distant metastases with a fatal course. In case 1, a 71-year-old patient presented with hematuria and pyuria. Computed tomography (CT) scan of the right kidney revealed a mass lesion, for which partial nephrectomy was performed. However, a follow-up CT imaging revealed distant metastases in the liver, the paraaortic lymph nodes and the bone. Despite molecular targeted therapy and irradiation, the patient succumbed due to tumor progression. In case 2, a 64-year-old patient presented with an incidentally identified mass lesion in the right kidney. A laparoscopic nephrectomy was performed, and a follow-up CT imaging revealed metastases in the skin and lungs. The cytology of pleural effusion revealed pleuritis carcinomatosa. Histologically, both cases were diagnosed as mucin-poor MTSCC with high-grade transformation, which comprised uniform tumor cells primarily forming slender tubules. The tumors contained low- and high-grade regions....Continue Reading

References

Oct 19, 2005·Virchows Archiv : an International Journal of Pathology·Sophie FerlicotAnnick Vieillefond
Nov 24, 2006·The American Journal of Surgical Pathology·Samson W FineJonathan I Epstein
Oct 23, 2008·The American Journal of Surgical Pathology·Jasreman DhillonVictor E Reuter
May 16, 2009·Human Pathology·Stela BulimbasicZoran Persec
Aug 4, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·James LarkinMartin Gore
Sep 13, 2013·The American Journal of Surgical Pathology·John R SrigleyUNKNOWN ISUP Renal Tumor Panel

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surgical resection

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