Mucin secretion in inflammatory bowel disease: comparison of a macrophage-derived mucin secretagogue (MMS-68) to conventional secretagogues

Inflammatory Bowel Diseases
K SperberS Itzkowitz

Abstract

We have described a novel macrophage-derived mucin secretagogue (MMS-68) that mediates mucin secretion in colon cancer cell lines and explants of normal and inflammatory bowel disease (IBD) mucosa. We compared MMS-68 induced mucin release with other known intestinal mucin secretagogues in normal colon explants and in the HT-29 colon cancer cell line, and to study the effects of MMS-68 on mucin release from inflamed and uninflamed ulcerative colitis (UC) and Crohn's disease (CD) mucosa. In normal colonic explants and HT-29 cells, each of the secretagogues including, MMS-68-induced mucin release two- to fivefold more than culture medium alone. In HT-29 cells, MMS-68 plus leukotriene C4 (LTC4) induced a 50% increase in mucin release over either secretagogue alone, and MMS-68 plus platelet-activating factor (PAF) markedly enhanced mucin release by eightfold over either secretagogue. In colonic explants from patients with UC and CD, the mucin release in response to MMS-68 was similar to that of normal colonic explants. Likewise, in isolated epithelial cells from CD and UC (whether involved or uninvolved), MMS-68-induced release was similar to that of epithelial cells isolated from normal colonic mucosa. The number of MMS-68-producin...Continue Reading

References

Jan 2, 1992·International Journal of Cancer. Journal International Du Cancer·Y NivY S Kim
Sep 1, 1991·Cellular Immunology·V L CohanR A Prendergast
Feb 1, 1991·The Journal of Allergy and Clinical Immunology·K SperberZ Marom
Feb 1, 1990·Journal of Clinical Pathology·D A McCormickA S Mee

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Citations

Nov 28, 2013·World Journal of Gastroenterology : WJG·Gerhard RoglerPeter L Lakatos
May 4, 2005·Diseases of the Colon and Rectum·Farshad AbirWalter E Longo
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Allison L MillerNicholas W Lukacs

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