Mucinous adenocarcinoma of the thymus: a distinct variant of thymic carcinoma

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Daichi MaedaMasashi Fukayama

Abstract

Primary thymic mucinous adenocarcinoma is a recently described subtype of thymic carcinoma, which behaves aggressively. The authors analyzed the clinical and pathological findings of three cases of thymic mucinous adenocarcinoma, and reviewed five cases previously reported in the English literature. The patients were two males and one female between the ages of 38 and 55 years. Macroscopically, the tumors were mostly solid and white to yellowish-white. Areas with a gelatinous appearance were present. Histologically, all of the tumors were adenocarcinomas with abundant mucin production, which resembled the mucinous adenocarcinomas of other organs. Malignant tumor cells in nests, tubules and cribriform structures floated in pools of extracellular mucin. In one case, associated thymic cysts were found at the periphery of the tumor. The cyst wall was partially lined by malignant mucinous epithelium, which showed transition from benign thymic epithelium. Immunohistochemically, all of the tumors showed positive immunoreactivity for cytokeratin (CK) 20 and carcinoembryonic antigen (CEA). CD5 was diffusely positive in one case, and focally positive in the other two cases. The prognoses of these cases were extremely poor, and two of the...Continue Reading

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May 28, 2013·The Annals of Thoracic Surgery·Hiroyoshi TsubochiHironori Ishida
Jun 19, 2012·American Journal of Clinical Pathology·Annikka Weissferdt, Cesar A Moran
Aug 23, 2011·International Journal of Cardiology·Hyun-Ju SeonJong Chun Park
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