Mucinous adenocarcinomas with intra-abdominal dissemination: a review of current therapy.

The Oncologist
Thomas Winder, Heinz-Josef Lenz

Abstract

Peritoneal carcinomatosis has been considered a terminal disease with a median survival time of 5.2-12.6 months. Systemic chemotherapy and cytoreductive surgery (CRS) have long been used to treat macroscopic disease, with limited success. However, a comprehensive treatment approach involving cytroreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) has evolved into a novel approach for peritoneal carcinomatosis. Surgery removes the primary cancer and any dissemination within the peritoneal cavity and adjuvant HIPEC eradicates macroscopic or microscopic tumor residue, thus reducing the risk for recurrence. This approach offers a new potential treatment option for patients with metastatic disease confined to the peritoneum. The present review provides an update of the most recent data on the current therapy for pseudomyxoma peritonei (PMP) and mucinous colorectal adenocarcinoma (MCA) with metastatic disease confined to the peritoneum.

References

Apr 1, 1976·Cancer·D A Symonds, A L Vickery
Sep 1, 1991·World Journal of Surgery·K E Levin, R R Dozois
Mar 1, 1987·Histopathology·O SasakiJ R Jass
Sep 1, 1988·The New England Journal of Medicine·B VogelsteinJ L Bos
Sep 1, 1985·The British Journal of Surgery·H C UmplebyR C Williamson
Jan 1, 1995·Annals of Surgery·P H Sugarbaker
Aug 1, 1994·The American Journal of Surgical Pathology·P B ClementR E Scully
Jan 1, 1993·Diseases of the Colon and Rectum·J B GreenJ E Ray
Dec 1, 1995·British Journal of Cancer·C Hanski
Jan 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H J LenzL Leichman
Jan 1, 1996·Journal of Gastroenterology and Hepatology·C S WuY C Kuo
Jan 1, 1996·Cancer Treatment and Research·P H Sugarbaker
Oct 23, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C G LeichmanP V Danenberg
Sep 25, 1999·Diseases of the Colon and Rectum·A NissanA M Cohen
Jan 6, 2000·Annals of Surgical Oncology·P H Sugarbaker, D Chang
Jul 11, 2000·Archives of Pathology & Laboratory Medicine·C C ComptonC Willett
Nov 7, 2000·Journal of Surgical Oncology·T NozoeK Sugimachi
Mar 27, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·H YanP H Sugarbaker
Jul 27, 2001·Journal of Surgical Oncology·P H Sugarbaker
Nov 26, 2002·The British Journal of Surgery·D G JayneF Seow-Choen
Feb 11, 2003·Diseases of the Colon and Rectum·Yukihide KanemitsuYoshitaka Yamamura
Jul 29, 2003·The American Journal of Surgical Pathology·Joseph MisdrajiRobert H Young
Jul 30, 2003·Cancer Metastasis Reviews·C Pablo CarmignaniPaul H Sugarbaker
Oct 11, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vic J VerwaalFrans A N Zoetmulder
Aug 18, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·O GlehenP Rat
Jan 19, 2005·British Journal of Cancer·S C GlasgowH L McLeod
Apr 29, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F V NegriP J Ross
Nov 17, 2005·Pathology International·Dong LiHiroshi Yokozaki
Nov 23, 2006·Diseases of the Colon and Rectum·Elizabeth M MurphyBrendan J Moran
Dec 22, 2006·Cancer Treatment Reviews·R M SmeenkF A N Zoetmulder

❮ Previous
Next ❯

Citations

Jan 10, 2013·Investigational New Drugs·Mazin F Al-KasspoolesKatherine F Roby
Feb 4, 2012·Annals of Surgical Oncology·T Clark GamblinDavid L Bartlett
Jun 19, 2012·World Journal of Surgical Oncology·Masakatsu NumataMakoto Akaike
Feb 5, 2013·Current Problems in Surgery·Curtis J WrayTien C Ko
Jul 22, 2015·Annals of Surgical Oncology·Kathrine BjersandPeter Nygren
Jun 1, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Y LiuY Yonemura
Jan 9, 2019·Journal of Gastrointestinal Cancer·Keishla M GarcíaÁngel M Rodríguez
May 4, 2018·Oncotarget·Magdalena CisłoWojciech Piotr Polkowski
Oct 3, 2018·World Journal of Gastroenterology : WJG·Aldona KasprzakWitold Szaflarski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.