Jan 26, 2016

Mucinous carcinoma of the breast: a comparative study on cytohistological findings associated with neuroendocrine differentiation

Cytopathology : Official Journal of the British Society for Clinical Cytology
R OhashiZ Naito

Abstract

Mucinous carcinoma (MCA) may show neuroendocrine differentiation (ND), but the cytological features characteristic of ND remains elusive. We compared fine needle aspiration (FNA) findings of MCA between cases with high and low degrees of ND. Histological sections of 37 MCA cases were immunohistochemically evaluated for expression of chromogranin A and synaptophysin, and were graded as 0 to 3+ degrees of ND. They were divided into low ND (grade 0 and 1+) and high ND (grade 2+ and 3+) groups. Pre-operative FNA samples of each group were assessed for cytological features. The mean age of the high ND group (n = 18) was higher than the low ND group (n = 19, P = 0.01). In FNA samples of the high ND group, 17 cases showed moderate to severe degrees of discohesiveness, but low ND cases mainly showed no or only mild discohesiveness (P < 0.001). Nine of the low ND cases displayed overlapped, cohesive cell clusters, whereas, in the high ND cases, the cells were arranged in a loose, flat and monolayered pattern (P = 0.045). Fourteen of the high ND cases had round nuclei, but oval nuclei were predominant in the low ND cases (P = 0.027). The nuclei were eccentrically located in 12 of the high ND cases but were centrally located in 14 of the ...Continue Reading

Mentioned in this Paper

CHGA gene
Patterns
Fine-needle Biopsy
Neuroendocrine Tumors
Immunohistochemistry
Carcinoma, Neuroendocrine
beta-funaltrexamine
Parathyroid Secretory Protein
Neuroendocrine Cell Differentiation
Oval Cell

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