PMID: 16531766Mar 15, 2006Paper

Mucinous colorectal cancers with chromosomal instability: a biologically distinct and aggressive subtype

Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B
Yoshihiro KazamaHirokazu Nagawa

Abstract

Colorectal cancers can progress through 2 pathways of genomic instability: microsatellite instability (MSI) and chromosomal instability (CSI). We investigated the influence of CSI and MSI on clinicopathological features and survival of 35 patients affected by mucinous colorectal cancers (MCRC). MSI status was determined by PCR amplification using 5 standard markers. Evidence for CSI was gathered by identifying loss of heterozygosity (LOH) of 4 loci (2p, 5q, 17p, 18q). We defined "MSI-MCRC" as those that showed MSI-H, and "CSI-MCRC" as those that showed LOH at 1 or more of these sites but did not show MSI-H. Among 35 cases, 18 cases (51.4%) were CSI-MCRC, whereas 11 cases (31.4%) were MSI-MCRC. Significant differences were found between CSI-MCRC and MSI-MCRC regarding the following clinicopathological features: tumor location (P=0.00026), lymph node metastasis (P=0.026), and TNM stage (P=0.026). Kaplan-Meier survival curves and log-rank analysis demonstrated that MSI-MCRC was associated with better prognosis than CSI-MCRC, although no significant difference was found (P=0.10). CSI-MCRC correlates more strongly with lymph node metastasis and advanced stage than MSI-MCRC. This indicates that CSI-MCRC is an aggressive subtype.

References

Apr 1, 1976·Cancer·D A Symonds, A L Vickery
Sep 1, 1985·The British Journal of Surgery·H C UmplebyR C Williamson
Jan 1, 1993·Diseases of the Colon and Rectum·J B GreenJ E Ray
Dec 1, 1995·British Journal of Cancer·C Hanski
Oct 18, 1996·Cell·K W Kinzler, B Vogelstein
Apr 10, 1997·Nature·C LengauerB Vogelstein
Jul 1, 1997·The Journal of Pathology·K M RopponenV M Kosma
Nov 7, 2000·Journal of Surgical Oncology·T NozoeK Sugimachi
Nov 26, 2002·Proceedings of the National Academy of Sciences of the United States of America·Martin A NowakChristoph Lengauer
Feb 11, 2003·Diseases of the Colon and Rectum·Yukihide KanemitsuYoshitaka Yamamura
Apr 30, 2003·Journal of Clinical Pathology·G Cserni
Mar 16, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sanjay KakarThomas C Smyrk

❮ Previous
Next ❯

Citations

Oct 29, 2009·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Toshiaki TanakaHirokazu Nagawa
Feb 13, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David S WilliamsOliver M Sieber
Jun 23, 2015·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Y S YoonJ C Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.