Mucinous gastric cancer presents with more advanced tumor stage and weaker β-catenin expression than nonmucinous cancer

Annals of Surgical Oncology
Min-Gew ChoiJae Moon Bae

Abstract

Mucinous gastric carcinoma (MGC) is a rare type of gastric cancer; its biological behavior is controversial. In this study, we attempted to clarify the clinical and pathological features as well as the prognostic significance of MGC. We also compared the expression patterns of CDX-2 and β-catenin between MGC and nonmucinous gastric carcinoma (NMGC). We reviewed the records of 9218 patients with gastric cancer who underwent gastric cancer surgery between January 1997 and December 2006. The clinicopathological features and clinical outcome of MGC (n = 197) were compared to NMGC (n = 9021). Immunohistochemical staining using the tissue array method was performed on MGC (n = 194) and NMGC (n = 89) tissues. MGC had a larger size and a higher frequency of Borrmann type I findings in advanced cases than NMGC. In addition, MGC had deeper invasion, more lymph node and lymphatic involvement, a more advanced tumor stage, and lower 5-year survival rates than NMGC. Age, depth of invasion, lymph node metastasis, lymphatic invasion, and curability were independent prognostic factors; but the mucinous histological type itself was not predictive of outcome. β-Catenin immunoreactivity was statistically significantly weaker in MGC than NMGC; howe...Continue Reading

References

Feb 15, 1992·Cancer·Y AdachiK Sugimachi
May 20, 1999·Yonsei Medical Journal·W J HyungK S Lee
Apr 26, 2001·Journal of Surgical Oncology·K YasudaS Kitano
Nov 15, 2001·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·H KawamuraT Hata
Feb 16, 2002·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Y AdachiK Sugimachi
Feb 16, 2002·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·T MizoshitaM Tatematsu
Feb 16, 2002·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Y AdachiS Kitano
Sep 11, 2002·Digestive Surgery·Sang Woo LimS K Kim
May 12, 2004·Cancer Biology & Therapy·Rong-Jun GuoJohn P Lynch
Jun 29, 2004·Journal of Clinical Gastroenterology·Kazuhiro YasudaSeigo Kitano
Apr 11, 2006·Annals of Surgical Oncology·Chikara KunisakiHiroshi Shimada
Aug 13, 2009·Molecular Cancer Research : MCR·Anas SaadeddinAbdolrahman Shams Nateri
Dec 1, 2002·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Hai Rim ShinJae Gahb Park

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Citations

Mar 13, 2012·World Journal of Gastroenterology : WJG·Anna Maria ChiaravalliEnrico Solcia
Feb 2, 2013·Cellular and Molecular Life Sciences : CMLS·Lui NgRoberta Pang
Feb 8, 2011·Medical Oncology·Chunming YinHuimian Xu
Feb 4, 2016·Gastroenterology Research and Practice·Chen Jian-HuiYu-Long He
Jul 16, 2014·Annals of Surgical Treatment and Research·Seong Yeob RyuDong Yi Kim
Apr 27, 2012·Journal of Surgical Oncology·Chang Ohk SungSung Kim
Jul 4, 2018·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J WeiN Zhang

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