Mucoadhesive alginate pastes with embedded liposomes for local oral drug delivery

International Journal of Biological Macromolecules
Yarden ShtenbergHavazelet Bianco-Peled

Abstract

Oral cancers are extremely common among adults with increasing incidences due to human papillomavirus, while treatment modalities are limited. This study aims to develop a new oral mucoadhesive delivery system based on the combination of alginate and liposomes. The polymer provides adhesion properties and induces local release of the drug-loaded carriers, while the liposomes protect the drug from degradation and improve its absorption into the cells. Three hybrid alginate/liposomes delivery systems were investigated: a hybrid paste, which presented excellent adhesive capabilities, yet fast burst release of 90% after 2h; a hybrid hydrogel, demonstrating controllable release rates of 5%, 30% or 60% after 2h but poor mucoadhesive properties. These findings led to the development of a hybrid cross-linked paste. Polymer retention studies demonstrated that 80% of the crosslinked paste was retained on tongue tissue compared to 50% retention of the non-cross-linked pastes, verifying its superior mucoadhesion. The hybrid cross-linked paste presented controllable release rate of 20% after 2h. Alginate paste incorporating doxorubicin loaded liposomes presented similar release rates and were highly effective in promoting cancer cell death....Continue Reading

Citations

Apr 9, 2019·Expert Opinion on Drug Delivery·Sajedehsadat MaghrebiPaul Joyce
Apr 24, 2019·Pharmaceutics·Julu TripathiSeong Hoon Jeong
Apr 24, 2019·The Journal of Pharmacology and Experimental Therapeutics·G KaurM N V Ravi Kumar
Jul 3, 2020·Journal of Biomaterials Science. Polymer Edition·Yanqin XuDan Wang
Jul 11, 2020·Pharmaceutics·Nieves IglesiasM-Violante de-Paz
Jun 24, 2020·Drug Delivery and Translational Research·Cristiano Ceron JaymeAntonio Claudio Tedesco
Jul 23, 2020·Frontiers in Bioengineering and Biotechnology·Mariana Isabel NevesCristina Carvalho Barrias
Mar 20, 2020·Journal of Biological Engineering·Farhad AbasalizadehAbolfazl Akbarzadeh
Jan 3, 2021·Advances in Colloid and Interface Science·Mahnaz AmiriMasoud Salavati-Niasari
May 26, 2018·International Journal of Pharmaceutics·Pedro M CastroManuela E Pintado
May 10, 2021·International Journal of Biological Macromolecules·Cesar Augusto Roque-BordaEduardo Festozo Vicente
Feb 11, 2019·ACS Biomaterials Science & Engineering·Denghua LuYuping Shan
Aug 29, 2021·Pharmaceuticals·Gustavo MoraesWalter L Siqueira
Oct 2, 2021·AAPS PharmSciTech·Mumuni SumailaYahya E Choonara

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