Mucoadhesive assessment of different antifungal nanoformulations

Bioinspiration & Biomimetics
L RoqueCatarina Reis

Abstract

Oral candidiasis is an important opportunistic fungal infection and polyenes and azoles are still the most used antifungal agents. However, the oral absorption resulting from most available treatments is generally poor and, consequently, a very high frequency of administrations of antifungal agents is strongly required. Therefore, the major challenge is to improve the retention of the antifungal agents in buccal mucosa, and the encapsulation into mucoadhesive systems may be considered as a possible strategy to achieve this objective. Three types of mucoadhesive polymeric nanoparticles (polylactic acid (PLA), polylactic-co-glycolic acid (PLGA) and alginate) were prepared using nystatin as model drug. The drug-loaded nanoparticles were then included in toothpaste, oral gel and oral films, respectively. The results demonstrated that the loaded nanoparticles were successfully produced, presenting a mean size between 300-900 nm and with a negative surface charge. Also, the determination of the encapsulation efficiency of all nanoparticles showed values above 70%. In terms of the in vitro mucoadhesion, the best formulation was the oral film loaded with the PLGA nanoparticles followed by the oral gel with PLA nanoparticles and thirdly...Continue Reading

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Citations

Apr 29, 2020·Bioinspiration & Biomimetics·Federico Bosia, Nicola M Pugno
Jan 24, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Samaneh Alaei, Hamid Omidian
Nov 11, 2019·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Julia F AlopaeusIngunn Tho
Jan 18, 2021·Colloids and Surfaces. B, Biointerfaces·Sam R AspinallVitaliy V Khutoryanskiy
Jan 10, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ana S MacedoPedro Fonte
Mar 27, 2021·Drug Delivery and Translational Research·Sevda ŞenelGülçin Akca
Aug 11, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Samaneh AlaeiHamid Omidian
Aug 29, 2021·Pharmaceuticals·Gustavo MoraesWalter L Siqueira

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