Mucoadhesive Chitosan Derivatives as Novel Drug Carriers

Current Pharmaceutical Design
Mohammad Ariful IslamChong-Su Cho

Abstract

Chitosan on its own is a well-established natural polymer and is widely regarded as a biodegradable, biocompatible and nontoxic material for drug delivery applications. Although unmodified chitosan has some mucoadhesive properties on its own, its bioavailability is limited due to its short retention time in the body. Moreover, the high solubility of chitosan at acidic pH levels limits its use for mucosal drug delivery (especially through the oral route). Chemically-modified mucoadhesive chitosan, especially thiolated chitosan, has arisen as an alternative to create novel mucosal drug delivery systems. The mucoadhesive properties that are conferred to the thiolated chitosan certainly set this novel class of second or third-generation thiomers apart. To understand the significance of mucoadhesive chitosan, we first present the mechanism of mucoadhesion and provide comprehensive coverage of description of a variety of chemical modifications to prepare mucoadhesive thiolated chitosan derivatives. We then present the plethora of applications of these modified chitosan variants in a wide range of drug delivery fields, including the delivery of antigens, proteins and genes through a variety of routes, including oral, nasal, pulmonary,...Continue Reading

Citations

Apr 4, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nazrul IslamVito Ferro
Mar 4, 2020·International Journal of Molecular Sciences·Yanan WangYantao Han
Jul 21, 2016·Nanoscale·Nazrul Islam, Vito Ferro
Nov 16, 2018·Biomaterials·Mohammad Ariful IslamChong Su Cho
Apr 21, 2021·Medical Mycology·Adelaide Fernandes CostaAndre Correa Amaral
May 1, 2021·Polymers·Rozita HassanSaiful Izwan Abd Razak
Jun 24, 2019·International Journal of Biological Macromolecules·Alap Ali ZahidAnwarul Hasan
May 28, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Alap Ali ZahidAnwarul Hasan
Jul 26, 2021·Tissue Engineering and Regenerative Medicine·Chong-Su ChoHyun-Joong Kim
May 13, 2019·ACS Biomaterials Science & Engineering·Yi-Chen Ethan Li

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