Mucoadhesive Microparticles Engineered for Ophthalmic Drug Delivery.

The Journal of Physics and Chemistry of Solids
Young Bin ChoyMark R Prausnitz

Abstract

Although topical drug delivery is a convenient route of administration to treat various eye diseases, it has serious limitations due to rapid clearance of the formulation from the surface of the eye. In this study, we engineered microparticles for both sustained drug delivery and prolonged residence time on the extraocular surface. Microparticles were fabricated by emulsification using poly(lactic-co-glycolic acid) (PLG) and poly(ethylene glycol) (PEG) as the core material and mucoadhesion promoter, respectively. The particle size was controlled to be less than 10 microm to avoid eye irritation and for eventual clearance through the lacrimal canals. In vitro mucoadhesion tests showed that PLG microparticles with PEG adhered better to the mucous membrane under the conditions employed in this study compared to the microparticles without PEG. When an aqueous suspension of microparticles with PEG was administered topically to the rabbit eye in vivo, microparticles were seen for up to 30 min on the ocular surface in the cul-de-sac, which was a dramatic increase in residence time as compared to conventional eye drop formulations. We conclude that mucoadhesive microparticles are promising vehicles for ophthalmic drug delivery.

References

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Citations

Jan 30, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Wanachat ChaiyasanWaree Tiyaboonchai
Jun 19, 2012·Expert Opinion on Drug Delivery·Priyanka PahujaPravin Pawar
May 12, 2012·International Journal of Pharmaceutics·Mariano LicciardiGaetano Giammona
Jun 28, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Patricia Checa-CasalenguaRocío Herrero-Vanrell
Sep 6, 2015·International Journal of Pharmaceutics·Panoraia I SiafakaDimitrios N Bikiaris
Apr 13, 2012·Macromolecular Bioscience·Giovanna PitarresiGaetano Giammona
Feb 20, 2014·Advanced Drug Delivery Reviews·Meng-Hua XiongJun Wang
Dec 5, 2009·Advanced Drug Delivery Reviews·Maria de la FuenteMaria Jose Alonso
Oct 25, 2016·Colloids and Surfaces. B, Biointerfaces·Wanachat ChaiyasanWaree Tiyaboonchai
Oct 22, 2016·Drug Delivery and Translational Research·I Bravo-OsunaR Herrero-Vanrell
Apr 6, 2017·Macromolecular Bioscience·Alan R MackieLuciano Marcelloni
Dec 7, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Shagufta KhanDilesh J Singhavi
Aug 24, 2018·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Sudeep Kumar GadeVenkata Vamsi Krishna Venuganti
Oct 6, 2020·Macromolecular Bioscience·Anna E CaprificoGianpiero Calabrese
Jan 15, 2021·Advances in Colloid and Interface Science·Brunella GrassiriAndreas Bernkop-Schnürch
Feb 7, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Clotilde JumelleReza Dana
Jun 25, 2021·Advanced Drug Delivery Reviews·Matthias MarczynskiOliver Lieleg
Jul 19, 2018·Molecular Pharmaceutics·Se-Na KimYoung Bin Choy
Jun 23, 2018·Biomacromolecules·Georgia PetrouThomas Crouzier

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