Mucoadhesive nanogels by ionotropic crosslinking of chitosan-g-oligo(NiPAam) polymeric micelles as novel drug nanocarriers

Nanomedicine
Maya Menaker RaskinAlejandro Sosnik

Abstract

To investigate a novel kind of mucoadhesive nanogel based on the supramolecular aggregation of chitosan-g-oligo(N-isopropylacrylamide) copolymers. Copolymers were synthesized by the graft-free radical polymerization of N-isopropylacrylamide on chitosan. The aggregation was studied by dynamic light scattering and nanoparticle tracking analysis (NTA), the nanostructure by transmission electron microscopy(TEM)/cryo-TEM, the mucoadhesiveness in vitro with mucin and the cytocompatibility in Caco2 cells. Copolymers (36-74% w/w N-isopropylacrylamide content) showed critical micellar concentration between 2.0 and 40.0 × 10(-3)% w/v and micelles were nanometric and positively charged. Physical stabilization was achieved with ionotropic crosslinking. TEM/cryo-TEM revealed multimicellar aggregates with good mucoadhesion and cytocompatibility properties. Micellar systems (1-10% w/v) increased the solubility of efavirenz up to 1249-fold. Results support the potential of these nano-drug delivery systems for improved mucosal administration of hydrophobic drugs.

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Citations

Feb 23, 2020·Pharmaceutics·Florina-Daniela CojocaruCosmin-Teodor Mihai
Aug 2, 2018·Bioengineering & Translational Medicine·Maya MonroeHonggang Cui
Jan 23, 2018·Polymers·Shaked EliyahuHavazelet Bianco-Peled
Oct 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Inbar SchlachetAlejandro Sosnik
Jan 15, 2021·Dental Materials : Official Publication of the Academy of Dental Materials·Vinicius RosaNikolaos Silikas
Mar 4, 2021·Drug Delivery and Translational Research·Sandra RoblaNoemi Csaba
Sep 11, 2020·Biomacromolecules·Alina Gabriela RusuLiliana Mititelu-Tartau
May 28, 2019·ACS Applied Materials & Interfaces·Inbar Schlachet, Alejandro Sosnik

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Methods Mentioned

BETA
transmission electron microscopy
dynamic light scattering
nuclear magnetic resonance

Software Mentioned

Skanlt TM
NTA
DigitalMicrograph
SpinWorks
GPC UniChrom
Win
Gatan
TEM AutoTune TM
STAR e
CONTIN

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