Mucoadhesive polymers with immobilized proteinase inhibitors for oral administration of protein drugs

Biomaterials
N A PlateL I Valuev

Abstract

A new approach to overcome the degradation of protein drugs by proteolytic enzymes and their targeting to the blood through the digestive apparatus was developed. The approach is based on the immobilization of drugs into the polymeric hydrogel containing glycoprotein--ovomucoid from duck egg whites. This glycoprotein inhibits the activity of proteolytic enzymes and acts as a biospecific ligand to lectins on the walls of the gastrointestinal tract.

Citations

Apr 1, 2005·Drug Discovery Today. Technologies·Andreas Bernkop-Schnürch
Mar 17, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Andreas Bernkop-SchnürchIsabella Brodnik
Jul 24, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·K H ChenV L Kett
Jun 9, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Andreas Bernkop-SchnürchChristian Huck
Jan 6, 2004·Journal of Pharmaceutical Sciences·Rakhi B Shah, Mansoor A Khan
Mar 22, 2014·Journal of the Science of Food and Agriculture·Zhipeng YuJingbo Liu
Jun 4, 2004·Expert Opinion on Biological Therapy·Nicholas A PeppasJames O Blanchette
Jul 18, 2015·Critical Reviews in Analytical Chemistry·Justyna WalczakBogusław Buszewski
Oct 27, 2005·Journal of Agricultural and Food Chemistry·Jennifer Kovacs-NolanYoshinori Mine

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