Mucobilia: current aspects in the management of a rare cause of malignant biliary obstruction

Journal of Hepato-biliary-pancreatic Sciences
Melanie-Antonietta BrownR S Chamberlain

Abstract

Mucobilia is a rare pathologic condition characterized by the abnormal secretion and accumulation of abundant mucus within the biliary tree. It is usually seen in association with mucin-producing hepatobiliary and pancreatic tumors. Neoplastic transformation of these tumors can range from low-grade dysplasia to invasive adenocarcinoma. Mucobilia usually presents with signs and symptoms of biliary obstruction, which may span from jaundice to cholangitis with progression to septic complications in severe cases. Occurrence of hepatolithiasis has also been attributed to mucobilia, which raises the concern of an increased risk for the development of cholangiocarcinoma. Precise radiological evaluation and detailed histopathological tissue diagnosis followed by execution of appropriate surgical therapy is vital in the integrated management of mucin-producing biliary neoplasms. This review will address the etiologies and symptomatology of mucobilia as well as discuss current aspects in the management of mucobilia and its causative etiologies.

References

Nov 1, 1992·Gastroenterology·P J CapizziD M Nagorney
Sep 1, 1988·Radiology·T KokuboM Minami
Mar 1, 1988·Cancer·K TakayasuG Ohno
Jan 1, 1987·The British Journal of Surgery·N S HadjisL H Blumgart
Oct 1, 1981·Cancer·Y IemotoS Fukamachi
Jul 1, 1995·World Journal of Surgery·S KuboH Hamba
Aug 1, 1996·The American Journal of Surgical Pathology·N V AdsayD S Klimstra
Apr 1, 1997·Journal of Surgical Oncology·D TsiftsisE Sanidas
Dec 31, 1998·Journal of Gastroenterology and Hepatology·M F Chen
Feb 19, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J M LäufferM W Büchler
Feb 16, 2000·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·R S Chamberlain, L H Blumgart
Jan 20, 2004·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jae Hoon LimKyung Jin Nam
Feb 11, 2004·Cancer·Sang Soo LeeYoung Il Min
Jul 21, 2005·Scandinavian Journal of Gastroenterology·Chung-Mou KuoChung-Huang Kuo
Oct 24, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y ZenYasuni Nakanuma
Jul 9, 2008·Scandinavian Journal of Gastroenterology·Yung-Kuan TsouYi-Yin Jan

Citations

Nov 13, 2016·Journal of Colloid and Interface Science·Vijayakumar N BoyaSubhash C Chauhan
Jul 25, 2018·Journal of the Belgian Society of Radiology·Anna EvdokimovaLaurent Dorthu

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.

Related Papers

HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery
R S Chamberlain, L H Blumgart
European Review for Medical and Pharmacological Sciences
M Gatto, D Alvaro
Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Wigdan Al-SukhniPaul D Greig
Hepatobiliary & Pancreatic Diseases International : HBPD INT
Jin-Fu TuQi-Yu Zhang
© 2021 Meta ULC. All rights reserved